AMP-V and Carnitine
Have you ever hit a fat burning plateau where no matter how hard you train or clean you eat, the fat just won’t seem to go!?
This can be frustrating and at times it may even feel like we are going backwards. If you have hit the plateau and tried all the protocols, tips and tricks with no luck, then keep reading because you may be surprised on what may be holding you back!
The best way to describe the mechanism of fat burning is relating it to an exclusive member’s club.
The club represents muscle cells in our body such as cardiac, smooth and skeletal muscles. Waiting at the door to get into the club is fat and sugar that will be turned to energy in the mitochondria of muscle cells.
Before lipids or glucose can be let into the cell they have to get past the bouncers at the door. These bouncers are two enzymes called Carnitine palmitoyltransferase and Malonyl-CoA. These guys only let in either sugar or fat at any one time. When our body is optimising fat as fuel (lipogenesis) the bouncer at the door is Carnitine palmitoyltransferase which allows lipids to enter the cells to where they will enter the mitochondria and convert down the electron transport chain into energy. To stay in the state of lipogenesis is absolute key to utilise fat as fuel. The only enzyme that can kick Carnitine palmitoyltransferase off bouncer duties is Malonyl-CoA which causes fat burning to come to a complete stop.
Glucose is our bodies first preference as an energy source which means Malonyl-CoA will be at the door letting glucose in to be used and converted into energy. Once we have efficiently used the blood glucose and the stored glycogen as energy, it is known as a glycogen depleted state or a carbohydrate deficit. This state allows Carnitine palmitoyltransferase to come back on the door and let lipids through to burn as energy.
Now we understand the mechanism of fat burning, let’s look at what can go wrong and cause us to stop burning fat:
Because fat burning stops when the enzyme Malonyl-CoA is present, the goal is to inhibit the release by reducing its key messenger for its release which is insulin. Insulin is critical in managing the body’s metabolism and is released in response to sweet taste sensations, non-nutritive sweeteners and rising blood sugar. Diets high in sugar, refined carbohydrates, fruits and dairy can all contribute to a spike in blood glucose levels and will switch the body into using sugar as fuel. Once your body burns through the glycogen stores it will go back into lipogenesis and fat burning will begin. If the body is tricked into thinking there is sugar coming in by consuming non-nutritive sweeteners, the fat burning process will stop. This can cause an unnecessary road block in your weight loss goals.
Your body may also stop burning fat when it has insufficient levels of the Carnitine palmitoyltransferase enzyme. As discussed before the Carnitine palmitoyltransferase enzyme is responsible for allowing lipids to enter through the cell membrane where they will enter the mitochondria and turn into energy. Carnitine is synthesised naturally in the liver by a combination of the amino acids lysine and methionine which further binds to coenzyme A to make Carnitine palmitoyltransferase enzyme. Supplementing with Carnitine can accelerate the bodies fat burning capabilities by increasing this enzyme if there is a deficiency.
What is the best protocol for Fat Burning?
1.Fasted cardio is extremely effective, in particularly first thing in the morning. This is when our body is in a glycogen depleted state and our insulin levels are low which allows the body to be in lipogenesis and without the circulation of insulin, inhibits muscle breakdown.
2.It is crucial to not give your body any reason to create an insulin spike. Avoid all carbohydrates, artificial sweeteners and smells that trick the body into thinking there is glycogen to burn. The best fuel you can give your body is fat!
3.Use a lipolytic fat burner like AMP-V which will force the body straight into lipolysis as soon as it hits your tongue! AMP-V contains a number of fats and essential oils that enhances lipolysis and fatty oxidation, improves fatty acid release, improves insulin sensitivity and increase fatty acid transport into the mitochondria. AMP-V contains good fats such as Conjugated Linoleic Acid (CLA) that triggers an internal response for your body to start burning fat. This enzymatic reaction increases the required pathways for lipogenesis, one of the main actions is to increase activity of the Carnitine palmitoyltransferase enzyme.
4.Stay in a Glycogen Depleted state throughout the day will keep the body in lipogeneses. Using AMP-V during the day can be your secret weapon in fat loss. The essential oils in AMP-V can help reduce hunger cravings and through the stabilisation of blood glucose levels, it can give you sustainable energy throughout the day.
5.Supplementing with Acetyl-L-Carnitine will ensure the body has optimal levels of Carnitine palmitoyltransferase enzyme for lipogenesis. Being deficient in this enzyme can inhibit lipids crossing into the mitochondria and being used as fuel. This can be one of the main reasons why we have a plateau in weight loss . Because insulin blocks lipolysis, Acetyl-L-Carnitine needs to be taken with water or an unflavoured beverage otherwise Carnitine will enter the bodies amino acid pool and not be utilised.
The Ultimate Fat Burning Pre-Workout
- 1ml of AMP-V.
- 2-6gms Acetyl-L-Carnitine.
- 200ml of water.
Directions: Shake and drink 15-20 minutes before fasted cardio.
Warning: depending on your bodies threshold to Acetyl-L-Carnitine you may experience the squirts if you have too much. Start at a lower dose and work your way up to avoid this.
Blog by Naturopath Racheal Lee.