Matt interviews Stephen Eddey, the principal of Health Schools Australia about insulin resistance and the role it plays in obesity and Polycystic Ovarian Syndrome (PCOS). Please excuse some of the glitches in the recording, we had problems with the Skype connection.
One of the key functions of the thyroid is to drive your metabolism. If your metabolism is slow, fat burning becomes difficult. Sure, you hit the gym, run the kilometres however; if your thyroid is low, you will only be burning fat optimally during these periods of exercise. Even if you exercise for one hour a day, that is still less than 5% of your day you are burning fat effectively. If you had an optimal metabolism and thyroid function, you would be burning fat for 24 hours a day, 7 days per week plus having more energy. Does that sound more appealing?
Symptom picture checklist for slow or under-active thyroid function
- generalised weight gain that is difficult to account for
- fluid retention
- apathy and depression
- too tired and cranky to care or tolerate ‘idiots’ (impatient towards others)
- cold or overly sensitive to cold breeze, drinks and foods
- swollen and bloated
- slow bowels with excessive bloating and gas and fullness
- poor circulation and fluid retention
- dry, weak and poor quality hair
- dry skin
- weak, brittle or poor quality finger and toe nails
- sluggish bowels and constipation
- burping, farting and gurgling guts
What is T432 Plus?
T432 Plus is a unique combination of super foods and spices used to maintain healthy metabolism from around the globe; including Ayurvedic, Traditional Chinese Medicine, and South American traditional medicine systems. The active ingredients in these super foods and spices have been isolated and concentrated and using the tools provided by modern science and combined with critical thyroid cofactors Zinc, Selenium and Iodine to ensure efficacy, consistency and reliability.
How does T432 Plus help fat burning?
Thyroid hormone for fat loss
Thyroid hormones control your metabolic rate, digestive function and thermogenic capacity. It is essential to control the thyroid hormone pathways to ensure that it works as a potent thermogenic compound. There are many factors that will alter the thyroid hormone conversion pathways. Here is your strategy to target your thyroid function.
- Support healthy thyroid hormone profile
- Maximise Thyroxine (T4) production and release
- Enhance the conversion of T4 to the more active form Triiodothyronine (T3)
- and then support conversion of T3 through to the potent thermogenic mitochondrial activating T2
- Boost the thermogenic form of thyroid hormone, Diiodothyronine (T2)
- Reduce reverse T3 (rT3) (a potential suppressor of thyroid function)
Figure 1. The conversion of T4 through to T3 and then through to T2
The Thyroid hormones
T4 is virtually the building blocks to the ‘active’ thyroid hormones. T4 has only 1/10th the activity of T3. A form of T4 is the synthetic drug (Oroxine) commonly prescribed by medical doctors for people with low thyroids. When an iodine is removed from T4 and converted to T3, the hormone becomes vastly more active.
T3 is the major pace maker of the body binding to nuclear receptors (thyroid hormone receptors). It regulates resting metabolic rate (increases the minimal level of calories that a person needs in order to sustain life while resting), thermogenesis, heart rate, increasing the consumption of both oxygen and energy in the body, the synthesis and degradation of the macromolecules, increase the rate of protein degradation and synthesis and controls the growth of bones.
rT3 (Reverse T3)
T4 can convert down two different pathways; either conversion to T3 or Reverse T3. T3 is 7x more potent thermogenic than T4. Reverse T3 is 1/100th as potent as T4 as a thermogenic and will bind and block the T3 receptors preventing the thermogenic T3 from acting directly and converting to the most potent thermogenic T2.
Until recent years, T2, because of its very low affinity for thyroid hormone receptors, was considered an inactive metabolite of thyroid hormones T4 and T3. Several observations, however, led to a reconsideration of this idea. T2 rapidly stimulates cellular mitochondrial respiration regulating thermogenesis and energy expenditure whilst those of T3 are initiated via the nucleus and involve genes and protein synthesis. T2 has a more rapid effect on mitochondrial respiration than T3 and the effects of T2 being evident as soon as 1 h after its injection, while that of T3 became evident only after 24h. T2 rapidly increases the activity of carnitine dependant enzymes, which are the rate limiting step for fat burning. This increases the ability of the mitochondria to import and oxidize fatty acids. T2 has the ability to reduce adiposity and dyslipidaemia and to prevent the development of liver steatosis (fatty liver) showing a rapid T2-induced increase in the ability of mitochondria to import and oxidize fatty acids.
Figure 2. This graph shows T2 is as potent as T3 but exerts its effects more rapidly.
What causes reduced thyroid hormone activity?
Thyroid raw material nutrient base
Yerba Mate (ilex paraguariensis)
Du Zhong (Eucommia ulmoides oliver leaf)
Cinnamon Bark (Cinnamomum zeylanicum)
Coleus Forskohlii (yielding 10mg Forskolin)
- Direct activation of adenylate cyclase to raise cyclic AMP levels
- Increase cAMP
- Increase lipolysis and thermogenesis
- Increase thyroid activity
- Enhance conversion of T4 to T3 and T2
- Reduces estrogen dominance by enhancing progesterone and thyroid hormone activity
Bladderwrack (Fucus vesiculosus)
- Exerts anti-estrogenic effects
- Aromatase inhibitor
- Inhibits the binding of estradiol to estrogen receptors
- Antioxidant, anti-allergic and anti-inflammatory
- good source of iodine
- Iodine is essential for healthy metabolic rate
- Iodine deficiency is a major cause of obesity and hypothyroidism
- Iodine deficiency causes estrogen dominance
- Bladderwrack is a potent source of iodine and other compounds including fucoidan and fucophlorethols, which have demonstrated powerful anti-estrogen properties.
- Bladderwrack extract inhibits the binding of estradiol to estrogen receptor alpha and beta.
- Phloroglucinol derivatives, belonging to the class of fucophlorethols, isolated from bladderwrack have been shown to be potent aromatase inhibitors.
Does T432 Plus interact with thyroid medication?
You should always consult your healthcare practitioner before you start any new diet, exercise or supplement regime. If you are on medication, seek advice from your prescribing doctor or pharmacist. It is ok to combine T432 Plus with thyroid medications if you are being supervised and monitored by your health care professional.
T432 Plus Summary
It is important to have optimal thyroid levels for many reasons. However; for people struggling with excessive weight, T432 Plus may help you achieve goals by optimising your thyroid and metabolism when you aren’t working out. After all, for most of the day, you aren’t in the gym. Don’t just limit your fat loss to less than 5% of the day. Optimal thyroid levels will give you the energy to get more out of life, avoid becoming fatigued and of course, reach your ideal goal body composition.
2017 Australia Fat Loss Supplement of the Year
These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.
- Bános C, Takó J, Salamon F, Györgyi S, Czikkely R Effect of ACTH-stimulated glucocorticoid hypersecretion on the serum concentrations of thyroxine-binding globulin, thyroxine, triiodothyronine, reverse triiodothyronine and on the TSH-response to TRH.Acta Med Acad Sci Hung. 1979;36(4):381- 94.
- Kellis, JT and Vickery, LE: Inhibition of Human Estrogen Synthetase (Aromatase) by Flavones. Science, 1984, 225: 1032-34.
L-Tyrosine 200mg, Du Zhong leaf extract, Yerba Mate leaf extract, Cinnamon Bark extract, Guarana seed extract, Coleus Root Extract, Pomegranate Peel Extract, Orgen-CM, Certified Organic Moringa Leaf Extract yielding approx. 30mcg of elemental chromium, Kelp Yielding 30mcg elemental iodine, Zinc Gluconate supplying 2.5mg of Elemental Zinc, Saccharomyces Cerevisiae selenium yielding 12.5mcg selenium.
Frequently asked questions
Can I take T432 Plus along with my Thyroid medication?
ATP recommends you only use T432 Plus with thyroid medication under the supervision of your prescribing medical professional. Monitor changes in blood test and body temperature to assess interactions.
Hypothetically T432 Plus can work synergistically with thyroid medication as it is formulated to enhance the efficient conversion and activity of thyroid medication and prevent the formation of reverse T3.
Will taking T432 Plus interrupt with taking the oral contraceptive pill?
Consult with your pharmacist for interactions with your particular form of contraception.
What is the recommended dosage for T432 Plus?
We recommend taking x1 capsule 3 times a day with main meals. Alternatively to find out what dose works for your body refer to our temperature chart on the product thumbnails at the top of the page.
What if T432 is keeping me awake at night?
If you are extremely sensitive to Naturally occurring caffeine content in the ingredients, we suggest having your last serve no later than 3pm and or earlier if you find that this time allotment is still keeping you awake.
Will this make my thyroid worse?
No, thankfully this is not a product designed to stimulate the thyroid in any particular direction, but rather provide the tools in the form of nutrients so that it can correct itself in the direction of change required by the body.
Welcome to the ATP Project Episode 96 Product Podcast – T432
In todays Podcast Matt, Steve and Jeff discuss ATP Sciences product T432
Matt explains why he created the product and how it works, including the 5 ways it can help you deal with unwanted fat tissue.
We are very proud that this year T432 won the award for fat burner of the year at the Arnold Classic Multi Sport Festival in Melbourne, Australia
As always this information is not designed to diagnose, treat, prevent or cure any condition and is for information purposed only –
Please discuss any information in this podcast with you health care professional before making any changes to your current lifestyle.
The evolution of ATP Science T432 fat burner has been many years in the making. ATP…
United States of America Orders
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Flat rate shipping (3-8 Working days): $9.95 USD
Express shipping (2-5 Working days): $14.95
Free Shipping on orders over $150.00 USD (3-8 Working days): FREE.
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Tracking Your Order:
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ATP Science aims to get all orders dispatched within 1-2 business days of you placing your order. ATP Science does not ship orders on public holidays and/or weekends.
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International Customers Please Read the Below (Especially UK customers)
Import taxes: You may have to pay import taxes and/or customs duties. You may also be required to pay a brokerage (handling) fee for the shipment. These charges are separate from your shipping charge and you will be billed directly for them via the shipping carrier. These shipping and tax rates vary from country to country and also depend upon the products being ordered. ATP Science has no control over these charges.
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Notes on returned packages: If an order is rejected by customs or unable to be delivered, and the cost to return the goods is greater than the value of the goods, ATP Science will instruct the carrier to abandon the package. The customer will not receive a refund for the merchandise or shipping cost. If an order is rejected by you unwilling to pay the duties or taxes ATP Science will only accept the rejected order if the value of the package is more than the cost of shipping to and back again and 10% restocking fee. If the cost to return the items exceed the cost of goods then ATP Science will instruct the agents to destroy the package and no refund will be available (and you may still be liable to pay your customs duties and taxes). If we do accept the return of the goods your refund will be the total of your order minus the cost to ship the goods back to us (which in some cases is quite a hefty fee).
We request that you contact your customs office and ask about import regulations and restrictions before placing your order. It is important for you to become familiar with Customs policies for your specific country before ordering.
Customs regulations differ by country and not knowing their regulations can result in your order incurring high import duties, the delivery being delayed or even returned. Please check with your Customs office to see if your country permits the shipment of the products you are planning to order from us and if any additional licenses or permits are needed.