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Block E3

USD $49.99

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Product Description

Block E3 – Body Shaping Serum

Block E3 is a shaping cream specifically formulated to estrogen dominant fatty areas (pictured below). The net result is:

  • an improved appearance of regional fat deposits that cause gynaecomastia in men (‘man boobs’)
  • an improved appearance of isolated pockets of fat on hips and buttocks in women and men
  • a secret weapon used by bodybuilders and physique models for pre-comp sculpting
  • a specifically formulated cream for tightening, smoothing and firming unsightly fat deposits

The effects of estrogen dominance include:

  • increases fat deposits and accumulation in isolated regions (pictured below)
  • the creation of an estrogen dominant body shape (pictured below)
  • an increased inter-muscular fat thereby reducing muscle definition
  • a reduced muscle mass and decrease muscle fibre size[1]

Estrogen body shape

As estrogen is fat soluble, it is stored in the subcutaneous fat in the following areas:

  • hips
  • buttocks
  • thighs
  • breasts and chest
  • backs of the arms
  • ‘love handles’
  • lower back
  • lower abdomen

Figure 1. The storage sites for the estrogens

Estrogen Dominance in Men

Raised intracellular oestradiol levels in men, induce and promote obesity, gynaecomastia (man boobs), metabolic syndrome, type two diabetes, benign prostatic hypertrophy and prostate cancer.2

Estrogen Dominance in women

Elevated estrogen: androgen ratio in women can manifest as changes in body shape that include increased subcutaneous fat on the lower abdomen, buttocks, hips and thighs. Isolated pockets of fat and cellulite on the widest point of the hips are a common sign.

Causes of Estrogen Dominance in men and women

  • increased aromatase activity, converting testosterone to estrogen
  • excessive stress
  • obesity
  • inflammation
  • reactive toxins and Xeno-estrogens (from petrochemicals, plastics, Bisphenol A (BPA), pollutions, pesticides)
  • anabolic steroids
  • certain foods that contain high levels of estrogen (e.g. milk)
  • medications that cause hypogonadism and have anti-androgenic effects (such as the contraceptive pill)
  • iodine deficiency

Estrogen Dominance Causes a Vicious Cycle

One of the key features of estrogen dominance is that it can be a self-perpetuating vicious cycle that can be isolated from the rest of the body. This means that the normal regulation and hormonal modulation pathways can sometimes not be able to control it or even be aware that it is happening in localised areas. Estrogen generated in fat cells and breast tissue is predominately used locally and not transported around the body and therefore does not necessarily activate negative feedback mechanisms and triggering subsequent reduction in estrogen production. The net result means you could be making estrogen without your body realising you already have too much of it in certain tissues.

Aromatase Converts Testosterone to Estrogen

Testosterone is metabolised to oestradiol by aromatase, in the cytoplasm of adipocytes, breast cells, endothelial cells and prostate cells, to increase intracellular oestradiol concentration at the expense of testosterone.

Increased aromatase activity will increase estrogen and lower testosterone and increase the activation of the mainly proliferative estrogen receptors to induce fat cell production in localised tissues.

Block E3 for site specific action.

Block E3 contains 3 effective synergistic ingredients to combat estrogen dominance. Block E3 is designed to work locally on regional fat deposits and breast tissue and not systemically. Block E3 is specifically designed to work on isolated pockets of fat and breast tissue.

Block E3 Contains the following active ingredients.

  • Oroxylum indicum (Midnight Horror)
  • Fucus vesiculosus (Bladderwrack)
  • Piper nigrum (Black Pepper) Essential Oil

Oroxylum indicum (Midnight Horror)

  • Aromatase inhibitor
  • Antioxidant
  • Anti-allergic
  • Anti-bacterial
  • Anti-inflammatory
  • Estrogen receptor blocker

Midnight horror contains Chrysin and Baicalein

Midnight Horror (Oroxylum indicum) is an extremely potent and natural source of the powerful flavones Chrysin (5, 7-dihydroxyflavone, or 5, 7-dihydroxy-2-phenyl-(9CI)) and Baicalein. Midnight horror is an aromatase inhibitor and estrogen blocker.

The flavones Chrysin and Baicalein inhibit the activity of aromatase (CYP19), thus decreasing estrogen biosynthesis and producing anti-estrogenic effects. Baicalein also blocks estrogen receptor activity.

Chrysin only works transdermally

Flavones such as Chrysin have very poor oral bioavailability, less than 5% of an oral dose can get past first pass metabolism and digestive tract. Flavones can however be efficiently absorbed when applied to the skin.

Fucus vesiculosus (Bladderwrack)

  • Exerts anti-estrogenic effects
  • Aromatase inhibitor
  • Inhibits the binding of oestradiol to estrogen receptors
  • Antioxidant, anti-allergic and anti-inflammatory
  • Possesses anti-aging activities for skin; improving dermal collagen integrity and elasticity.
  • Inhibits glycation, which is damage to protein structures caused by binding and oxidation of sugar.

Bladderwrack is an estrogen blocker

Many scientific papers have discussed and studied the Asian diet its association with lower incidences of estrogen related cancers. Researchers have always surmised it to be due to the soy, seafood and green tea. More recently researchers have been led to believe it may actually be due to the kelp and its iodine content they consume regularly and use as part of cosmetics and skincare.

Bladderwrack is an estrogen receptor blocker

Bladderwrack is a potent source of iodine and other compounds including fucoidan and fucophlorethols, which have demonstrated powerful anti-estrogen properties.3 Bladderwrack extract inhibits the binding of oestradiol (E2) to estrogen receptor alpha and beta.2 Bladderwrack is also an aromatase inhibitor. Phloroglucinol derivatives, belonging to the class of fucophlorethols, isolated from bladderwrack have been shown to be potent aromatase inhibitors.5

Bladderwrack is a rich source of beneficial iodine

Bladderwrack is a rich source of Iodine, which has important functions in breast tissue in men and women. Iodine helps to maintain normal breast tissue architecture and function and low iodine produces a hyper-estrogenic state. Iodine deficiency alters the structure and function of mammary gland alveolar cells and makes them highly sensitive to stimulation by oestradiol.

Topical application of the active ingredients

One of the great challenges in medicine is getting the drug/nutrient/herb to the area where it is needed. E3 Blocker deals with this by delivering its active ingredients straight to where it is needed. As mentioned, taking some agents orally isn’t the best way to take them. Here at ATP Science we take this problem seriously and have developed products like Block E3 which directly targets the area. See the graphic below on how our products get to where they are needed.

Figure 2. The mechanism of action for the delivery of the active ingredients in Block E3 and Subcut

Your Estrogen Detox Strategy

  • Avoid exposure to exogenous estrogen (plastics and pollutants etc.) and isolate and address your cause (e.g. obesity or hypothyroid function). Fat cells produce estrogen so losing fat may be your first option. See ATP Science AMP-V product data for effective fat loss solutions.
  • Block the pathways such as the aromatase pathway, which makes excessive estrogen from your valuable testosterone
  • Make sure the active components are working where they are needed and not taken orally with the hope they find their way to the affected areas.

It is best to avoid excessive estrogens in the body in the first place. Most excessive estrogens come from carrying too much body fat. Thus, the obvious strategy to reduce estrogens is to burn fat by fasting exercise (first thing in the morning) and eating a lower carbohydrate diet. Consider Block E3 and supplementing with Alpha Prime and / or Alpha Venus (other great ways to reduce estrogen).

Excessive estrogen untreated can lead to poorer health outcomes. If you believe your hormones are not balanced, please see your health care practitioner.

“Every bikini girl needs her beauty sleep but first I like to apply @atpscience Subcut and Block E3 all over my buns and thighs ? nighty night xx”@isabellatuminello



These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.


Black Pepper Essential Oil

Fucus Vesiculosus (Bladderwrack)

Oroxylum indicum (chrysin)


Frequently asked questions

What is the difference between Subcut and Block E3?

Subcut and Block E3 are both body shaping serums; however they have very different modes of action.

Subcut is a fat mobiliser. It works by forcing fat to be released from storage in subcutaneous fatty tissue thereby allowing the fat to be burnt as a source of fuel. Subcut works on any area with obvious subcutaneous fatty tissue storage sites.

Block E3 is an estrogen blocker. Estrogen can inhibit fat burning and lock up fat in subcutaneous fatty tissue storage sites. Block E3 works specifically on estrogen dominant fatty tissue sites. Refer to estrogen dominant sites image above.

How long before I can start to see results with Block E3?

Block E3 starts absorbing within minutes. Take accurate measurements using tape measure and ideally measure skin folds with callipers before commencing Block e3 and you will notice changes to these objective measurements within the first 4 weeks. We recommend you use block e3 for 4 to 12 week cycle to maximise results.

Why do we have to rub the Block E3 on the wrists?

The Block E3 formulation used to be only as a prescription only transdermal aromatase inhibitor estrogen blocker to be used to prevent the conversion of testosterone to estrogen for the prevention and treatment of gynaecomastia and to maximise the results from testosterone replacement therapy. The directions for use were to apply to the wrist for systemic activity and also use locally to target isolated pockets of estrogen dominant fatty tissue.

The Block E3 no longer has those instructions on the label as its intended purpose is as a body shaping serum. The new instructions are to use specifically on the isolated pockets of estrogen dominant fat.

When is the best time to apply the Block E3?

After showers to your estrogen dominant areas of the body. Use 1-2 times daily and ensure one of those times is at night after a shower before bed.

Can i Use Block E3 on my stomach?

Yes, you can, in women with endometriosis, this may be extremely beneficial. However, be mindful if there is an underlying PCOS condition to avoid the lower abdominal area.


Episode 21 – Transdermal Delivery Systems

In this episode Matt and Jeff discuss the benefits of transdermal methods of delivery of ingredients. They breakdown how it works and why it can be superior to other delivery methods such as oral, sublingual and intravenous. Matt explains how they deliver nutrients through the skin and the benefits of using penetration enhancers. Lastly they pull apart the “bro science” of putting ingredients that don’t work transdermally and finish off with a few FAQs on sleep and cramping.
Estrogen 101

Find Out More about Episode 21 – Transdermal Delivery Systems

Episode 109 – Block E3 – Product Podcast

In today product podcast Jeff, Matt and Steve breakdown Block E3. Block E3 was created to target stubborn oestrogen dominant fat pockets on both men and womens bodies. Matt talks about how it is different from Subcut and how Block E3 works, when to use it and what it can be used for.

As always this information is not designed to diagnose, treat, prevent or cure any condition and is for information purposes only – please discuss any information in this podcast with you health care professional before making any changes to your current lifestyle

Find Out More about Episode 109 – Block E3 – Product Podcast

Blog Shipping

United States of America Orders

ATP Science offers a flat rate standard shipping option, express shipping and free standard shipping on orders over $150.00 USD to all US customers. We use a 3rd party logistics company in the US (Texas) to ship all of our orders so they will come from within the US. Shipping prices are below for the US:

Flat rate shipping (3-8 Working days): $9.95 USD
Express shipping (2-5 Working days): $14.95
Free Shipping on orders over $150.00 USD (3-8 Working days): FREE.

Tracking Your Order:

ATP Science aims to get all orders dispatched within 1-2 business days of you placing your order. ATP Science do not ship orders on public holidays and/or weekends.

ATP Science does not take responsibility of any delays of your parcel/order from the moment it is handed to the courier driver.

ATP Science does not take responsibility for parcels that have been given an authority to leave on the premises (examples include but are not limited to; leave at the front door, leave over the fence, leave on front porch etc).

Australian Online Orders

ATP Science offers a flat rate standard shipping option to all Australian customers. We use Australia Post for all of our parcels shipped within Australia.

  • Australian Flat Rate Shipping (2-14 working days): $9.95
  • Express Shipping (1-5 Working Days): $15.00
  • Free Standard Shipping on all orders over $150.00


Tracking Your Order:

Australia Post:

ATP Science aims to get all orders dispatched within 1-2 business days of you placing your order. ATP Science do not ship orders on public holidays and/or weekends.

ATP Science does not take responsibility for any delays of your parcel/order from the moment it is handed to the courier driver.

ATP Science aims to get all orders dispatched within 1-2 business days of you placing your order. ATP Science does not ship orders on public holidays and/or weekends.

ATP Science does not take responsibility for any delays of your parcel/order from the moment it is handed to the courier driver.

Orders from International Customers (excluding USA)

ATP Science offers a flat rate standard shipping option to all International customers. We use Australia Post and DHL for all of our parcels shipped overseas (excluding USA).

Flat rate shipping (3-7 Working Days): $9.95 USD.

Track your Order:
Australia Post:

ATP Science aims to get all orders dispatched within 1-2 business days of you placing your order. ATP Science does not ship orders on public holidays and/or weekends.

ATP Science does not take responsibility for any delays of your parcel/order from the moment it is handed to the courier driver.

International Customers Please Read the Below (Especially UK customers)

Import taxes: You may have to pay import taxes and/or customs duties. You may also be required to pay a brokerage (handling) fee for the shipment. These charges are separate from your shipping charge and you will be billed directly for them via the shipping carrier. These shipping and tax rates vary from country to country and also depend upon the products being ordered. ATP Science has no control over these charges.

Declaration of Value and Product Description: International shipments are processed with a commercial invoice as required to ship internationally. Customs may make additional requests based on local laws and regulations. Due to the complexity of some requests, we cannot guarantee that the additional information requested will be provided. The requests may differ depending on the order value, regulations, and other unpredictable factors.

Your shipping address, phone number, and email address: Please make sure your shipping address, phone number, and email are full and complete. The phone number or email may be used by the shipping company to contact you in case they have problems delivering your order. ATP Science is not responsible if you incorrectly enter your address on your order and will not be responsible for your parcel if it is incorrectly delivered because of this.

Customs & Regulatory information: ATP Science will not be liable for packages refused or held by customs for delivery. ATP Science does not take responsibility for any extra charged to the customer by customs/duty/VAT.

Address or other customer error: If a package is returned to ATP Science due to an address error (or any other error) made by the customer, the customer will be responsible for any shipping fees incurred. A refund will be issued for merchandise only, minus a 10% restocking fee*, upon receipt of the returned package. This also applies to customer refusal of a package (in which the customer will have the cost of the return shipment taken from the total refund).

Violation of laws: If a package is returned to ATP Science due to a violation of a country’s laws or import regulations, the customer will be responsible for any and all fees billed to ATP Science as a result. A refund will be issued for merchandise only, upon receipt of the returned package. If an order is seized and destroyed by customs due to regulatory issues, the customer will not receive credit for the merchandise or shipping cost.

Notes on returned packages: If an order is rejected by customs or unable to be delivered, and the cost to return the goods is greater than the value of the goods, ATP Science will instruct the carrier to abandon the package. The customer will not receive a refund for the merchandise or shipping cost. If an order is rejected by you unwilling to pay the duties or taxes ATP Science will only accept the rejected order if the value of the package is more than the cost of shipping to and back again and 10% restocking fee.  If the cost to return the items exceed the cost of goods then ATP Science will instruct the agents to destroy the package and no refund will be available (and you may still be liable to pay your customs duties and taxes). If we do accept the return of the goods your refund will be the total of your order minus the cost to ship the goods back to us (which in some cases is quite a hefty fee).

We request that you contact your customs office and ask about import regulations and restrictions before placing your order. It is important for you to become familiar with Customs policies for your specific country before ordering.

Customs regulations differ by country and not knowing their regulations can result in your order incurring high import duties, the delivery being delayed or even returned. Please check with your Customs office to see if your country permits the shipment of the products you are planning to order from us and if any additional licenses or permits are needed.


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