GutRight –

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  2.  Published online 2017 Nov 2. doi:  10.1371/journal.pntd.0005916 PMCID: PMC5667730
  3. “Omic” investigations of protozoa and worms for a deeper understanding of the human gut “parasitome”
  4. Valeria Marzano,1 Livia Mancinelli,2 Giorgia Bracaglia,2 Federica Del Chierico,1 Pamela Vernocchi,1 Francesco Di Girolamo,1 Stefano Garrone,2 Hyppolite Tchidjou Kuekou,3 Patrizia D’Argenio,3 Bruno Dallapiccola,4 Andrea Urbani,5,6 and Lorenza Putignani1,7,* Review Part 1: The Human Gut Microbiome in Health and Disease
  5. Bull MJ, Plummer NT, Integr Med (Encinitas). 2014 Dec; 13(6):17-22. Review Gut microbiota in autism and mood disorders.
  6. Mangiola F, Ianiro G, Franceschi F, Fagiuoli S, Gasbarrini G, Gasbarrini A World J Gastroenterol. 2016 Jan 7; 22(1):361-8
  7. Lampe JW.et al. Diet, genetic polymorphisms, detoxification, and health risks. Altern Ther Health Med. 2007 Mar-Apr;13(2):S108-11. Immunology. Second Edition 2013 Lippincott Williams & Wilkins. Thao Doan MD et al.
  8. Cellular and Molecular Immunology. International Edition. Eight Edition (2015) Abul K. Abbas et al. Elsevier Saunders
  9. Acta Biotheor. 2017 Jun;65(2):117-134. Skewed Exposure to Environmental Antigens Complements Hygiene Hypothesis in Explaining the Rise of Allergy.  Allaerts W, Chang TW.
  10. Annu Rev Biophys. 2013;42:493-514. Evolution in microbes. Kussell E1.
  11. Clinica Chimica Acta. Volume 451, Part A, 7 December 2015, Pages 97-102. The role of the gut microbiome in the healthy adult status. ValeriaD’Argenioa
  12. The role of the gut microbiome in the healthy adult status Author links open overlay panelValeriaD’Argenioab1FrancescoSalvatoreabc1
  13. Analysis of the gut microbiome and plasma short-chain fatty acid profiles in a spontaneous mouse model of metabolic syndrome Kazuchika Nishitsuji1, Jinzhong Xiao2, Ryosuke Nagatomo3, Hitomi Umemoto4, Yuki Morimoto5, Hiroyasu Akatsu6, Koichi Inoue3 & Koichi Tsuneyama Scientific Reports | 7: 15876 Received: 24 August 2017 Accepted: 6 November 2017
  14. BMC Microbiol. 2017; 17: 120. Published online 2017 May 22. doi:  10.1186/s12866-017-1027-1Review The obese gut microbiome across the epidemiologic transition.
  15. Dugas LR, Fuller M, Gilbert J, Layden BT Emerg Themes Epidemiol. 2016; 13():2. BMC Microbiol. 2017; 17: 120. Published online 2017 May 22. doi:  10.1186/s12866-017-1027-1
  16. An obesity-associated gut microbiome with increased capacity for energy harvest. Turnbaugh PJ, Ley RE, Mahowald MA, Magrini V, Mardis ER, Gordon JI Nature. 2006 Dec 21; 444(7122):1027-31.
  17. Review Effects of gut microbes on nutrient absorption and energy regulation. Krajmalnik-Brown R, Ilhan ZE, Kang DW, DiBaise JK Nutr Clin Pract. 2012 Apr; 27(2):201-14.
  18. Microbiome. 2015; 3: 50. Published online 2015 Oct 27. doi:  10.1186/s40168-015-0116-
  19. Microbiomes of the dust particles collected from the International Space Station and Spacecraft Assembly Facilities. Aleksandra Checinska, Alexander J. Probst, Parag Vaishampayan, James R. White, Deepika Kumar, Victor G. Stepanov, George E. Fox, Henrik R. Nilsson, Duane L. Pierson, Jay Perry, and Kasthuri Venkateswaran
  20. Christopher Newell,corresponding author1 Marc R. Bomhof,2 Raylene A. Reimer,1,2 Dustin S. Hittel,1 Jong M. Rho,3,4,5 and Jane Shearer1,2 Mol Autism. 2016; 7(1): 37. Ketogenic diet modifies the gut microbiota in a murine model of autism spectrum disorder
  21. Biofilm Formation as a Pathogenicity Factor of Medically Important Fungi. Taissa Vieira Machado Vila and Sonia Rozental. http://dx.doi.org/10.5772/62768
  22. Verma A1, Gaffen SL2, Swidergall M3. J Fungi (Basel). 2017 Oct 31;3(4). pii: E60. Innate Immunity to Mucosal Candida Infections.
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  24. Chandra, D. M. Kuhn, P. K. Mukherjee, L. L. Hoyer, T. McCormick, and M. A. Ghannoum, “Biofilm formation by the fungal pathogen Candida albicans: development, architecture, and drug resistance,” J. Bacteriol., vol. 183, no. 18, pp. 5385–5394, 2001.
  25. Sameh Soliman,1,2 Dina Alnajdy,1 Ali A. El-Keblawy,3 Kareem A. Mosa,3,4 Ghalia Khoder,5 and Ayman M. Noreddin6,7 Pharmacogn Rev. 2017 Jul-Sep; 11(22): 104–122. Plants’ Natural Products as Alternative Promising Anti-Candida Drugs
  26. J Mol Microbiol Biotechnol. 2007;13(4):243-7
  27. The antifungal activity of RsAFP2, a plant defensin from raphanus sativus, involves the induction of reactive oxygen species in Candida albicans Aerts AM1, François IE, Meert EM, Li QT, Cammue BP, Thevissen K.J Appl Microbiol. 2018 Jan;124(1):126-135. doi: 10.1111/jam.13629. Epub 2017 Dec 7.
  28. Antimicrobial activity of broccoli (Brassica oleracea var. italica) cultivar Avenger against pathogenic bacteria, phytopathogenic filamentous fungi and yeast. Pacheco-Cano RD1, Salcedo-Hernández R1,2, López-Meza JE3, Bideshi DK4,5, Barboza-Corona JE1,2.Asian Pac J Trop Biomed. 2014 Feb;4(2):104-8. doi: 10.1016/S2221-1691(14)60217-3.
  29. Hibiscus sabdariffa extract inhibits in vitro biofilm formation capacity of Candida albicans isolated from recurrent urinary tract infections. Alshami I1, Alharbi AE1. J Food Sci. 2017 Apr;82(4):1020-1027. doi: 10.1111/1750-3841.13672. Epub 2017 Mar 8
  30. Correlation between Antimicrobial, Antioxidant Activity, and Polyphenols of Alkalized/Nonalkalized Cocoa Powders. Todorovic V1, Milenkovic M2, Vidovic B1, Todorovic Z3, Sobajic S1. J Clin Diagn Res. 2017 Jan;11(1):ZC114-ZC117. doi: 10.7860/JCDR/2017/22810.9304. Epub 2017 Jan 1.
  31. “Rhetoric to Reality”- Efficacy of Punica Granatum Peel Extract on Oral Candidiasis: An in vitro Study. Madugula P1, Reddy S2, Koneru J3, Rao AS4, Sruthi R1, Dalli DT1. Int J Biol Macromol. 2018 Mar;108:391-400. doi: 10.1016/j.ijbiomac.2017.12.039. Epub 2017 Dec 7.
  32. PgTeL, the lectin found in Punica granatum juice, is an antifungal agent against Candida albicans and Candida krusei. da Silva PM1, de Moura MC1, Gomes FS2, da Silva Trentin D3, Silva de Oliveira AP1, de Mello GSV4, da Rocha Pitta MG5, de Melo Rego MJB5, Coelho LCBB1, Macedo AJ6, de Figueiredo RCBQ7, Paiva PMG1, Napoleão TH8. Exp Biol Med (Maywood). 2017 Mar;242(6):625-634. doi: 10.1177/1535370216688571. Epub 2017 Jan 17
  33. Biological activities of Rosmarinus officinalis L. (rosemary) extract as analyzed in microorganisms and cells. de Oliveira JR1, de Jesus D1, Figueira LW1, de Oliveira FE1, Pacheco Soares C2, Camargo SE1, Jorge AO1, de Oliveira LD1.
  34. Promising results of cranberry in the prevention of oral Candida biofilms. Girardot M, Guerineau A, Boudesocque L, Costa D, Bazinet L, Enguehard-Gueiffier C, Imbert C. Pathog Dis. 2014 Apr;70(3):432-9. doi: 10.1111/2049-632X.12168.
  35. Prosperini et al. A Review of the Mycotoxin ENN B Frontiers in Public Health November 2017 | Volume 5 | Article 304.
  36. Hallmann E1, Kazimierczak R1, Marszałek K2, Drela N3, Kiernozek E3, Toomik P4, Matt D5, Luik A5, Rembiałkowska E1. J Agric Food Chem. 2017 Sep 20;65(37):8171-8183.2017 Sep 7. The Nutritive Value of Organic and Conventional White Cabbage (Brassica Oleracea L. Var. Capitata) and Anti-Apoptotic Activity in Gastric Adenocarcinoma Cells of Sauerkraut Juice Produced Therof.
  37. Regular consumption of sauerkraut and its effect on human health: a bibliometric analysis. Raak C, Ostermann T, Boehm K, Molsberger F. Glob Adv Health Med. 2014 Nov;3(6):12-8
  38. Kim DH, Jeong D, Kim H, Seo KH. Modern perspectives on the health benefits of kefir in next generation sequencing era: improvement of the host gut microbiota. Crit Rev Food Sci Nutr. 2018 Jan 16:0.
  39. Maki R1, Matsukawa M1, Matsuduka A1, Hashinaga M2, Anai H3, Yamaoka Y2, Hanada K3, Fujii C1. Jpn J Nurs Sci. 2017 Nov 6. Therapeutic effect of lyophilized, Kefir-fermented milk on constipation among persons with mental and physical disabilities. Med Oncol. 2017 Sep 27;34(11):183. doi: 10.1007/s12032-017-1044-9
  40. Kefir: a powerful probiotics with anticancer properties Sharifi M1, Moridnia A2, Mortazavi D3, Salehi M3, Bagheri M3, Sheikhi A2.
  41. Gamboa-Gómez CI1, González-Laredo RF1, Gallegos-Infante JA1, Pérez MD2, Moreno-Jiménez MR1, Flores-Rueda AG1, Rocha-Guzmán NE1. Food Technol Biotechnol. 2016 Sep;54(3):367-374. Antioxidant and Angiotensin-Converting Enzyme Inhibitory Activity of Eucalyptus camaldulensis and Litsea glaucescens Infusions Fermented with Kombucha Consortium.
  42. Naifang Fu, 1 Juncai Wu, 1 Lv Lv, 2 Jijun He, 2 and Shengjun Jiang 1 Braz J Microbiol. 2015 Oct-Dec; 46(4): 1245–1255. Anti-foot-and-mouth disease virus effects of Chinese herbal kombucha in vivo
  43. Vázquez-Cabral BD1, Larrosa-Pérez M2, Gallegos-Infante JA1, Moreno-Jiménez MR1, González-Laredo RF1, Rutiaga-Quiñones JG3, Gamboa-Gómez CI1, Rocha-Guzmán NE4. Chem Biol Interact. 2017 Jun 25;272:1-9. Oak kombucha protects gainst oxidative stress and inflammatory processes.
  44. Beer Polyphenols and Menopause: Effects and Mechanisms—A Review of Current Knowledge Berner Andrée Sandoval-Ramírez, Rosa M. Lamuela-Raventós, Ramon Estruch, Gemma Sasot, Monica Doménech, Anna Tresserra-Rimbau Oxid Med Cell Longev. 2017; 2017: 4749131
  45. Pérez Gutiérrez and Perez: Raphanus sativus (Radish) TheScientificWorldJOURNAL (2004) 4, 811–837
  46. Pérez Gutiérrez and Perez: Raphanus sativus (Radish) The Scientific World JOURNAL (2004) 4, 811–837
  47. Abdull Razis AF1, De Nicola GR, Pagnotta E, Iori R, Ioannides C. Eur J Nutr. 2013 Apr;52(3):1279-85. A glucosinolate-rich extract of Japanese Daikon perturbs carcinogen-metabolizing enzyme systems in rat, being a potent inducer of hepatic glutathione S-transferase.
  48. Christine A. Houghton, Robert G. Fassett, and Jeff S. Coombes Oxid Med Cell Longev. 2016; 2016: 7857186.Sulforaphane and Other Nutrigenomic Nrf2 Activators: Can the Clinician’s Expectation Be Matched by the Reality?
  49. Eri Kobayashi, Takafumi Suzuki, and Masayuki Yamamoto. Oxidative Medicine and Cellular Longevity Volume 2013 (2013), Article ID 529219, 7 pages. Roles Nrf2 Plays in Myeloid Cells and Related Disorders
  50. Megan Migliozzi,1,† Dil Thavarajah,1,†* Pushparajah Thavarajah,1,2 and Powell Smith1,3 Nutrients. 2015 Nov; 7(11): 9285–9298. Lentil and Kale: Complementary Nutrient-Rich Whole Food Sources to Combat Micronutrient and Calorie Malnutrition
  51. http://healthyfitnatural.com/health-benefits-of-kale/
  52. Megan Migliozzi,1,† Dil Thavarajah,1,†* Pushparajah Thavarajah,1,2 and Powell Smith1,3 Nutrients. 2015 Nov; 7(11): 9285–9298. Lentil and Kale: Complementary Nutrient-Rich Whole Food Sources to Combat Micronutrient and Calorie Malnutritio
  53. Pharmaceuticals (Basel). 2016 Aug 12;9(3). pii: E48. Nutraceutical Improvement Increases the Protective Activity of Broccoli Sprout Juice in a Human Intestinal Cell Model of Gut Inflammation. Ferruzza S1, Natella F2, Ranaldi G3, Murgia C4, Rossi C5, Trošt K6, Mattivi F7, Nardini M8, Maldini M9, Giusti AM10, Moneta E11, Scaccini C12, Sambuy Y13, Morelli G14, Baima S15.
  54. World J Gastroenterol. 2015 Nov 21;21(43):12457-67. Sulforaphane-rich broccoli sprout extract improves hepatic abnormalities in male subjects. Kikuchi M1, Ushida Y1, Shiozawa H1, Umeda R1, Tsuruya K1, Aoki Y1, Suganuma H1, Nishizaki Y1.
  55. Adriana Conzatti’, Fernanda Carolina Telles da Silva Frdes2, Ingrid Dalira Schweigert Perry3-4 and Carolina Guerini de Souza4-5 Clinical and molecular evidence of the consumption of broccoli
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  58. World J Gastroenterol. 2015 Nov 21;21(43):12457-67. Sulforaphane-rich broccoli sprout extract improves hepatic abnormalities in male subjects. Kikuchi M1, Ushida Y1, Shiozawa H1, Umeda R1, Tsuruya K1, Aoki Y1, Suganuma H1, Nishizaki Y1.
  59. Evid Based Complement Alternat Med. 2014;2014:974840. Effects of young barley leaf powder on gastrointestinal functions in rats and its efficacy-related physicochemical properties. Ikeguchi M1, Tsubata M1, Takano A1, Kamiya T1, Takagaki K1, Ito H2, Sugawa-Katayama Y3, Tsuji H2.
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  61. Evid Based Complement Alternat Med. 2014;2014:974840. Effects of young barley leaf powder on gastrointestinal functions in rats and its efficacy-related physicochemical properties. Ikeguchi M1, Tsubata M1, Takano A1, Kamiya T1, Takagaki K1, Ito H2, Sugawa-Katayama Y3, Tsuji H2.
  62. Food Chem. 2017 Nov 1;234:190-198. In vitro approaches to assess the effects of açai (Euterpe oleracea) digestion on polyphenol availability and the subsequent impact on the faecal microbiota. Alqurashi RM1, Alarifi SN2, Walton GE2, Costabile AF3, Rowland IR2, Commane DM2.
  63. J Agric Food Chem. 2008 Dec 24;56(24):11688-93. In vitro anti-inflammatory activity of larch (Larix decidua L.) sawdust. Pferschy-Wenzig EM1, Kunert O, Presser A, Bauer R.
  64. Hassan ST, Berchová K, Šudomová M. Ceska Slov Farm. 2016 Winter;65(1):10-4. Antimicrobial, antiparasitic and anticancer properties of Hibiscus sabdariffa (L.) and its phytochemicals: in vitro and in vivo studies.
  65. Franco R1, Oñatibia-Astibia A, Martínez-Pinilla E. Nutrients. 2013 Oct 18;5(10):4159-73. Health benefits of methylxanthines in cacao and chocolate.
  66. Xenofon Tzounis, Ana Rodriguez-Mateos, Jelena Vulevic, Glenn R Gibson, Catherine Kwik-Uribe, and Jeremy PE Spencer  Prebiotic evaluation of cocoa-derived flavanols in healthy humans by using a randomized, controlled, double-blind, crossover intervention study. Am J Clin Nutr January 2011 vol. 93 no. 1 62-72
  67. Xenofon Tzounis, Ana Rodriguez-Mateos, Jelena Vulevic, Glenn R Gibson, Catherine Kwik-Uribe, and Jeremy PE Spencer  Prebiotic evaluation of cocoa-derived flavanols in healthy humans by using a randomized, controlled, double-blind, crossover intervention study. Am J Clin Nutr January 2011 vol. 93 no. 1 62-72
  68. Franco R1, Oñatibia-Astibia A, Martínez-Pinilla E. Nutrients. 2013 Oct 18;5(10):4159-73. Health benefits of methylxanthines in cacao and chocolate
  69. García-Aguilar L, Rojas-Molina A, Ibarra-Alvarado C, Rojas-Molina JI, Vázquez-Landaverde PA, Luna-Vázquez FJ, Zavala-Sánchez MA. Nutritional value and volatile compounds of black cherry (Prunus serotina) seeds. Molecules. 2015 Feb 17;20(2):3479-95
  70. Dzotam JK, Simo IK, Bitchagno G, Celik I, Sandjo LP, Tane P, Kuete V. In vitro antibacterial and antibiotic modifying activity of crude extract, fractions and 3′,4′,7-trihydroxyflavone from Myristica fragrans Houtt against MDR Gram-negative enteric bacteria. BMC Complement Altern Med. 2018 Jan 15;18(1):15.
  71. Marx W, Ried K, McCarthy AL, Vitetta L, Sali A, McKavanagh D, Isenring L. Ginger-Mechanism of action in chemotherapy-induced nausea and vomiting: A review. Crit Rev Food Sci Nutr. 2017 Jan 2;57(1):141-14
  72. Nabavi SF, Di Lorenzo A, Izadi M, Sobarzo-Sánchez E, Daglia M, Nabavi SM. Antibacterial Effects of Cinnamon: From Farm to Food, Cosmetic and Pharmaceutical Industries. Nutrients. 2015 Sep 11;7(9):7729-4
  73. Cassettari VMG, Machado NC, Lourenção PLTA, Carvalho MA, Ortolan EVP. Combinations of laxatives and green banana biomass on the treatment of functional constipation in children and adolescents: a randomized study. J Pediatr (Rio J). 2018 Jan 5. pii: S0021-7557(17)30638-1.
  74. Li Z, He X, Liu F, Wang J, Feng J. A review of polysaccharides from Schisandra chinensis and Schisandra sphenanthera: Properties, functions and applications. Carbohydr Polym. 2018 Mar 15;184:178-190.
  75. Aida Zarfeshany, Sedigheh Asgary,1 and Shaghayegh Haghjoo Javanmard  Adv Biomed Res. 2014; 3: 100. Potent health effects of pomegranate
  76. Luqman S1, Dwivedi GR, Darokar MP, Kalra A, Khanuja SP. Altern Ther Health Med. 2007 Sep-Oct;13(5):54-9.
  77. Potential of rosemary oil to be used in drug-resistant infections. Azuma K, Osaki T, Kurozumi S, Kiyose M, Tsuka T, Murahata Y, Imagawa T, Itoh N, Minami S, Sato K, Okamoto Y. Anti-inflammatory effects of orally administered glucosamine oligomer in an experimental model of inflammatory bowel disease. Carbohydr Polym. 2015 Jan 22;115:448-56.
  78. Azuma K, Osaki T, Kurozumi S, Kiyose M, Tsuka T, Murahata Y, Imagawa T, Itoh N, Minami S, Sato K, Okamoto Y. Anti-inflammatory effects of orally administered glucosamine oligomer in an experimental model of inflammatory bowel disease. Carbohydr Polym. 2015 Jan 22;115:448-56.
  79. Denis MC, Roy D, Yeganeh PR, Desjardins Y, Varin T, Haddad N, Amre D, Sané AT, Garofalo C, Furtos A, Patey N, Delvin E, Tremblay E, Marette A, Beaulieu JF, Levy E. Apple peel polyphenols: a key player in the prevention and treatment of experimental inflammatory bowel disease. Clin Sci (Lond). 2016 Dec 1;130(23):2217-2237.
  80. Alfaro-Viquez E, Esquivel-Alvarado D, Madrigal-Carballo S, Krueger CG, Reed JD. Cranberry proanthocyanidin-chitosan hybrid nanoparticles as a potential inhibitor of extra-intestinal pathogenic Escherichia coli invasion of gut epithelial cells. Int J Biol Macromol. 2018 Jan 8;111:415-420.
  81. Ruiz-Ruiz JC1, Moguel-Ordoñez YB2, Segura-Campos MR3.Crit Rev Food Sci Nutr. 2017 Aug 13;57(12):2680-2690. Biological activity of Stevia rebaudiana Bertoni and their relationship to health.
  82. Christopher Newell,corresponding author1 Marc R. Bomhof,2 Raylene A. Reimer,1,2 Dustin S. Hittel,1 Jong M. Rho,3,4,5 and Jane Shearer1,2 Mol Autism. 2016; 7(1): 37. Ketogenic diet modifies the gut microbiota in a murine model of autism spectrum disorder
  83. Danielle N. Cooper,1 Mary E. Kable,2 Maria L. Marco,3 Angela De Leon,1 Bret Rust,1,2 Julita E. Baker,1 William Horn,2 Dustin Burnett,2 and Nancy L. Keim1,2,* Nutrients. 2017 Feb; 9(2): 173. The Effects of Moderate Whole Grain Consumption on Fasting Glucose and Lipids, Gastrointestinal Symptoms, and Microbiota
  84. Gut microbiota and glucometabolic alterations in response to recurrent partial sleep deprivation in normal-weight young individuals Christian Benedict 1 , Heike Vogel 2,3 , Wenke Jonas 2,3 , Anni Woting 4  Michael Blaut 4 , Annette Schürmann 2,3 Jonathan Cedernaes 1,* MOLECULAR METABOLISM 5 (2016) 1175e1186
  85. Guo Y1, Huang ZP2,3, Liu CQ3, Qi L4, Sheng Y5, Zou DJ6. Eur J Endocrinol. 2018 Jan;178(1):43-56. Modulation of the gut microbiome: a systematic review of the effect of bariatric surgery.
  86. Diet and Feeding Pattern Affect the Diurnal Dynamics of the Gut Microbiome Amir Zarrinpar,1,2 Amandine Chaix,1 Shibu Yooseph,3 and Satchidananda Panda1, Cell Metabolism 20, 1006–1017, December 2, 2014

Multi-food –

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  2. Kehoe SH1, Chopra H2, Sahariah SA2, Bhat D3, Munshi RP4, Panchal F4, Young S5, Brown N1, Tarwande D6, Gandhi M2, Margetts BM7, Potdar RD2, Fall CH1. Effects of a food-based intervention on markers of micronutrient status among Indian women of low socio-economic status. Br J Nutr. 2015 Mar 14;113(5):813-21. doi: 10.1017/S000711451400419X. Epub 2015 Feb 13.
  3. Kawashima A1, Madarame T, Koike H, Komatsu Y, Wise JA. Four week supplementation with mixed fruit and vegetable juice concentrates increased protective serum antioxidants and folate and decreased plasma homocysteine in Japanese subjects. Asia Pac J Clin Nutr. 2007;16(3):411-21.
  4. Zhou SS, Zhou Y. Excess vitamin intake: An unrecognized risk factor for obesity. World J Diabetes 2014; 5: 1-13 [PMID: 24567797 DOI: 10.4239/wjd.v5.i1.1]
  5. Zhou SS, Zhou YM, Li D, Lun YZ. Dietary methyl-consuming compounds and metabolic syndrome. Hypertens Res 2011; 34:1239-1245 [PMID: 21814217 DOI: 10.1038/hr.2011.133]
  6. Zhou SS, Li D, Zhou YM, Sun WP, Liu QG. B-vitamin consumption and the prevalence of diabetes and obesity among the US adults: population based ecological study. BMC Public Health 2010; 10: 746 [PMID: 21126339 DOI: 10.1186/1471-2458-10-746]
  7. Li D, Sun WP, Zhou YM, Liu QG, Zhou SS, Luo N, Bian FN, Zhao ZG, Guo M. Chronic niacin overload may be involved in the increased prevalence of obesity in US children. World J Gastroenterol 2010; 16: 2378-2387 [PMID: 20480523 DOI: 10.3748/wjg.v16.i19.2378]
  8. Zhou SS1, Li D1, Chen NN1, Zhou Y1. Vitamin paradox in obesity: Deficiency or excess?World J Diabetes. 2015 Aug 25;6(10):1158-67. doi: 10.4239/wjd.v6.i10.1158.
  9. Redox Biol. 2015;4:272-8. doi: 10.1016/j.redox.2014.12.017. Epub 2015 Jan 16.The shifting perception on antioxidants: the case of vitamin E and β-carotene. Vrolijk MF1, Opperhuizen A2, Jansen EH3, Godschalk RW4, Van Schooten FJ4, Bast A4, Haenen GR4.
  10. Int J Cancer. 2014 Jul 1;135(1):178-85. doi: 10.1002/ijc.28641. Epub 2013 Dec 12. Effects of α-tocopherol and β-carotene supplementation on cancer incidence and mortality: 18-year postintervention follow-up of the Alpha-tocopherol, Beta-carotene Cancer Prevention Study. Virtamo J1, Taylor PR, Kontto J, Männistö S, Utriainen M, Weinstein SJ, Huttunen J, Albanes D.
  11. Int J Cancer. 2010 Jul 1;127(1):172-84. doi: 10.1002/ijc.25008. Beta-carotene supplementation and cancer risk: a systematic review and metaanalysis of randomized controlled trials. Druesne-Pecollo N1, Latino-Martel P, Norat T, Barrandon E, Bertrais S, Galan P, Hercberg S.
  12. Cochrane Database Syst Rev. 2012 Oct 17;10:CD002141. doi: 10.1002/14651858.CD002141.pub2. Drugs for preventing lung cancer in healthy people. Cortés-Jofré M1, Rueda JR, Corsini-Muñoz G, Fonseca-Cortés C, Caraballoso M, Bonfill Cosp X.
  13. Cochrane Database Syst Rev. 2012 Mar 14;(3):CD007176. doi: 10.1002/14651858.CD007176.pub2. Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases. Bjelakovic G1, Nikolova D, Gluud LL, Simonetti RG, Gluud C.
  14. Clin Nutr. 2016 Feb;35(1):77-82. doi: 10.1016/j.clnu.2015.02.017. Epub 2015 Mar 24. Vitamin D3 supplementation and body composition in persons with obesity and type 2 diabetes in the UAE: A randomized controlled double-blinded clinical trial. Sadiya A1, Ahmed SM2, Carlsson M3, Tesfa Y2, George M2, Ali SH2, Siddieg HH2, Abusnana S2.
  15. Eur J Endocrinol. 2015 Mar;172(3):235-41. doi: 10.1530/EJE-14-0870. Vitamin D3 increases in abdominal subcutaneous fat tissue after supplementation with vitamin D3. Didriksen A1, Burild A2, Jakobsen J2, Fuskevåg OM2, Jorde R3.
  16. Sadiya A1, Ahmed SM2, Carlsson M3, Tesfa Y2, George M2, Ali SH2, Siddieg HH2, Abusnana S2. Vitamin D3 supplementation and body composition in persons with obesity and type 2 diabetes in the UAE: A randomized controlled double-blinded clinical trial. Clin Nutr. 2016 Feb;35(1):77-82. doi: 10.1016/j.clnu.2015.02.017. Epub 2015 Mar 24.
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  18. Sadiya A1, Ahmed SM1, Skaria S1, Abusnana S1.
  19. Eur J Clin Nutr. 2015 Jun;69(6):707-11. doi: 10.1038/ejcn.2014.251. Epub 2014 Nov 19. Vitamin D supplementation in obese type 2 diabetes subjects in Ajman, UAE: a randomized controlled double-blinded clinical trial. Sadiya A1, Ahmed SM1, Carlsson M2, Tesfa Y1, George M1, Ali SH1, Siddieg HH1, Abusnana S1.
  20. Eur J Endocrinol. 2013 Oct 1;169(5):559-67. doi: 10.1530/EJE-13-0233. Print 2013 Nov. The serum 25-hydroxyvitamin D response to vitamin D supplementation is related to genetic factors, BMI, and baseline levels. Didriksen A1, Grimnes G, Hutchinson MS, Kjærgaard M, Svartberg J, Joakimsen RM, Jorde R.
  21. Eur J Endocrinol. 2015 Mar;172(3):235-41. doi: 10.1530/EJE-14-0870. Vitamin D3 increases in abdominal subcutaneous fat tissue after supplementation with vitamin D3. Didriksen A1, Burild A2, Jakobsen J2, Fuskevåg OM2, Jorde R3.
  22. Zhao Y1, Monahan FJ1, McNulty BA1, Brennan L1, Gibney MJ1, Gibney ER2. α-Tocopherol Stereoisomers in Human Plasma Are Affected by the Level and Form of the Vitamin E Supplement Used.J Nutr. 2015 Oct;145(10):2347-54. doi: 10.3945/jn.115.213280. Epub 2015 Aug 19.
  23. Clemente HA1, Ramalho HM, Lima MS, Grilo EC, Dimenstein R. Maternal supplementation with natural or synthetic vitamin E and its levels in human colostrum. J Pediatr Gastroenterol Nutr. 2015 Apr;60(4):533-7.
  24. Ping Tou Gee Unleashing the untold and misunderstood observations on vitamin E
  25. Scaglione F1, Panzavolta G. Folate, folic acid and 5-methyltetrahydrofolate are not the same thing Xenobiotica. 2014 May;44(5):480-8. doi: 10.3109/00498254.2013.845705. Epub 2014 Feb 4.
  26. Marchetta CM1, Devine OJ2, Crider KS3, Tsang BL4, Cordero AM5, Qi YP6, Guo J7, Berry RJ8, Rosenthal J9, Mulinare J10, Mersereau P11, Hamner HC12. Assessing the association between natural food folate intake and blood folate concentrations: a systematic review and Bayesian meta-analysis of trials and observational studies.Nutrients. 2015 Apr 10;7(4):2663-86. doi: 10.3390/nu7042663.
  27. Smith AD, Kim YI, Refsum H. Is folic acid good for everyone? Am J Clin Nutr. 2008 Mar;87(3):517-33.
  28. Obeid R1,2, Fedosov SN3,4, Nexo Cobalamin coenzyme forms are not likely to be superior to cyano- and hydroxyl-cobalamin in prevention or treatment of cobalamin deficiency. Mol Nutr Food Res. 2015 Jul;59(7):1364-72. doi: 10.1002/mnfr.201500019. Epub 2015 May 12.
  29. Tóshiko Takahashi-Iñiguez,†,1 Enrique García-Hernandez,2 Roberto Arreguín-Espinosa,2 and María Elena Flores1Role of vitamin B12 on methylmalonyl-CoA mutase activity* J Zhejiang Univ Sci B. 2012 Jun; 13(6): 423–437
  30. McNulty H, Strain JJ, Hughes CF, Ward M. Riboflavin, MTHFR genotype and blood pressure: A personalized approach to prevention and treatment of hypertension.Mol Aspects Med. 2016 Oct 6. pii: S0098-2997(16)30058-9. doi: 10.1016/j.mam.2016.10.002. [Epub ahead of print]
  31. Brosnan JT. Homocysteine and cardiovascular disease: interactions between nutrition, genetics and lifestyle.Can J Appl Physiol. 2004 Dec;29(6):773-80.
  32. Strohle A, et al. Micronutrients at the Interface between Inflammation and Infection – ascorbic acid and calciferol. Part 1: General Overview with a focus on Ascorbic Acid. Inflammation and Allergy – Drug Targets, 2011, 10,54-63
  33. Inflamm Allergy Drug Targets. 2011 Feb;10(1):54-63. Micronutrients at the interface between inflammation and infection–ascorbic acid and calciferol: part 1, general overview with a focus on ascorbic acid. Ströhle A1, Wolters M, Hahn A.
  34. Ströhle A1, Hahn A. [Vitamin C and immune function Med Monatsschr Pharm. 2009 Feb;32(2):49-54; quiz 55-6.
  35. J Nutr Sci Vitaminol (Tokyo). 2014;60(6):367-79. doi: 10.3177/jnsv.60.367. Vitamin C in the treatment and/or prevention of obesity. Garcia-Diaz DF1, Lopez-Legarrea P, Quintero P, Martinez JA.
  36. Frei B1, Birlouez-Aragon I, Lykkesfeldt Authors’ perspective: What is the optimum intake of vitamin C in humans? J.Crit Rev Food Sci Nutr. 2012;52(9):815-29. doi: 10.1080/10408398.2011.649149.
  37. Oral Dis. 2016 Sep;22(6):463-93. doi: 10.1111/odi.12446. Epub 2016 Apr 14. Vitamin C: the known and the unknown and Goldilocks. Padayatty SJ1, Levine M1.
  38. Biochim Biophys Acta. 2014 Sep;1843(9):1909-16. doi: 10.1016/j.bbamcr.2014.05.016. Epub 2014 Jun 4
  39. Subcellular compartmentation of ascorbate and its variation in disease states
  40. Bánhegyi G1, Benedetti A2, Margittai E3, Marcolongo P2, Fulceri R2, Németh CE4, Szarka A5.
  41. Wilhelm Jahnen-Dechent and Markus Ketteler. Magnesium basics. Clin Kidney J. 2012 Feb; 5(Suppl 1): i3–i14. 

Prototype 8 –

  1. Lanni, A., Moreno, M., Cioffi, M., and Goglia, F. (1992) Mol. Cell. Endocrinol., 86,
    143-148.
  2. Lanni, A., Moreno, M., Cioffi, M., and Goglia, F. (1993) J. Endocrinol., 136, 59-64.
  3. O’Reilly, I., and Murphy, M. P. (1992) Acta Endocrinol. (Copenh.), 127, 542-546.
  4.  F. Goglia. Review – Biological Effects of 3,5-Diiodothyronine (T2). Biochemistry (Moscow), Vol. 70, No. 2, 2005, pp. 164-172. Translated from Biokhimiya, Vol. 70, No. 2, 2005, pp. 203-213.
  5. Bános C, Takó J, Salamon F, Györgyi S, Czikkely R Effect of ACTH-stimulated
    glucocorticoid hypersecretion on the serum concentrations of thyroxine-binding
    globulin, thyroxine, triiodothyronine, reverse triiodothyronine and on the TSHresponse to TRH.Acta Med Acad Sci Hung. 1979;36(4):381-94.
  6. Chandra AK, De N. Goitrogenic/antithyroidal potential of green tea extract in
    relation to catechin in rats. Food Chem Toxicol. 2010 Aug-Sep;48(8-9):2304-11. doi: 10.1016/j.fct.2010.05.064. Epub 2010 Jun 1.
  7. Sakamoto Y, Mikuriya H, Tayama K, Takahashi H, Nagasawa A, Yano N, Yuzawa K,Ogata A, Aoki N. Goitrogenic effects of green tea extract catechins by dietary
    administration in rats. Arch Toxicol. 2001 Dec;75(10):591-6.
  8. Berger MM, Reymond MJ, Shenkin A, Rey F, Wardle C, Cayeux C, Schindler C,
    Chioléro RL. Influence of selenium supplements on the post-traumatic alterations of the thyroid axis: a placebo- controlled trial. Intensive Care Med. 2001 Jan;27(1):91-100.
  9. Nishiyama S, Futagoishi-Suginohara Y, Matsukura M, Nakamura T, Higashi A,
    Shinohara M, Matsuda I. Zinc supplementation alters thyroid hormone metabolism in disabled patients with zinc deficiency. J Am Coll Nutr. 1994 Feb;13(1):62-7.
  10. da-Silva WS, Harney JW, Kim BW, Li J, Bianco SD, Crescenzi A, Christoffolete MA,
    Huang SA, Bianco AC. The small polyphenolic molecule kaempferol increases cellular energy expenditure and thyroid hormone activation. Diabetes. 2007 Mar;56(3):767-76.
  11. JENS JUUL HOLST. The Physiology of Glucagon-like Peptide 1. Physiol Rev 87:
    1409–1439, 2007; doi:10.1152/physrev.00034.2006.
  12. Noriko HIRATA, et al. Testosterone 5a-Reductase Inhibitory Active Constituents of Piper nigrum Leaf. Biol. Pharm. Bull. 30(12) 2402—2405 (2007)
  13. Panda S, Kar A Withania somnifera and Bauhinia purpurea in the regulation of circulating thyroid hormone concentrations in female mice..J Ethnopharmacol. 1999 Nov 1;67(2):233-9.
  14. Jatwa R, Kar A. Amelioration of metformin-induced hypothyroidism by Withania
    somnifera and Bauhinia purpurea extracts in Type 2 diabetic mice. Phytother Res. 2009 Aug;23(8):1140-5. doi: 10.1002/ptr.2765.
  15. Yahya F, Mamat SS, Kamarolzaman MF, Seyedan AA, Jakius KF, Mahmood ND,
    Shahril MS, Suhaili Z, Mohtarrudin N, Susanti D, Somchit MN, Teh LK, Salleh MZ,
    Zakaria ZA.Hepatoprotective Activity of Methanolic Extract of Bauhinia purpurea
    Leaves against Paracetamol-Induced Hepatic Damage in Rats. Evid Based
    Complement Alternat Med. 2013;2013:636580.
  16. Azevedo CR, Maciel FM, Silva LB, Ferreira AT, da Cunha M, Machado OL, Fernandes KV, Oliveira AE, Xavier-Filho Isolation and intracellular localization of insulin-like proteins from leaves of Bauhinia variegata. J Braz J Med Biol Res. 2006 Nov;39(11):1435-44..
  17. Pereira DF, Kappel VD, Cazarolli LH, Boligon AA, Athayde ML, Guesser SM, Da Silva EL, Silva FR.Influence of the traditional Brazilian drink Ilex paraguariensis tea on glucose homeostasis Phytomedicine. 2012 Jul 11. [Epub ahead of print]
  18. Boaventura BC, Di Pietro PF, Stefanuto A, Klein GA, de Morais EC, de Andrade F,
    Wazlawik E, da Silva EL Association of mate tea (Ilex paraguariensis) intake and
    dietary intervention and effects on oxidative stress biomarkers of dyslipidemic
    subjectsNutrition. 2012 Jun;28(6):657-64..
  19. Gosmann G, Barlette AG, Dhamer T, Arçari DP, Santos JC, de Camargo ER, Acedo S, Gambero A, Gnoatto SC, Ribeiro ML Phenolic compounds from maté (Ilex
    paraguariensis) inhibit adipogenesis in 3T3-L1 preadipocytes. Plant Foods Hum
    Nutr. 2012 Jun;67(2):156-61..
  20. Phytother Res. 2012 Apr 18. doi: 10.1002/ptr.4700. [Epub ahead of print] Prevention of Hydrogen Peroxide-Induced Red Blood Cells Lysis by Ilex paraguariensis Aqueous Extract: Participation of Phenolic and Xanthine Compounds. Peralta IN, Cogoi L,  Filip R, Anesini C.
  21. Kang YR, Lee HY, Kim JH, Moon DI, Seo MY, Park SH, Choi KH, Kim CR, Kim SH,
    Oh JH, Cho SW, Kim SY, Kim MG, Chae SW, Kim O, Oh HG. Anti-obesity and antidiabetic effects of Yerba Mate (Ilex paraguariensis) in C57BL/6J mice fed a high-fat diet. Lab Anim Res. 2012 Mar;28(1):23-9. Epub 2012 Mar 21.
  22. Lima IF, De Dea Lindner J, Soccol VT, Parada JL, Soccol CR. Development of an
    Innovative Nutraceutical Fermented Beverage from Herbal Mate (Ilex paraguariensis A.St.-Hil.) Extract.Int J Mol Sci. 2012;13(1):788-800. Epub 2012 Jan 13.
  23. Hussein GM, Matsuda H, Nakamura S, Hamao M, Akiyama T, Tamura K, Yoshikawa M.Mate tea (Ilex paraguariensis) promotes satiety and body weight lowering in mice: involvement of glucagon-like peptide-1. Biol Pharm Bull. 2011;34(12):1849-55.
  24. Klein GA, Stefanuto A, Boaventura BC, de Morais EC, Cavalcante Lda S, de Andrade F, Wazlawik E, Di Pietro PF, Maraschin M, da Silva EL.Mate tea (Ilex paraguariensis) improves glycemic and lipid profiles of type 2 diabetes and pre-diabetes individuals: a pilot study.J Am Coll Nutr. 2011 Oct;30(5):320-32.
  25. de Andrade F, de Albuquerque CA, Maraschin M, da Silva EL. Safety assessment of yerba mate (Ilex paraguariensis) dried extract: results of acute and 90 days
    subchronic toxicity studies in rats and rabbits. Food Chem Toxicol. 2012
    Feb;50(2):328-34. Epub 2011 Oct 14.
  26. Hussein GM, Matsuda H, Nakamura S, Akiyama T, Tamura K, Yoshikawa M.
    Protective and ameliorative effects of maté (Ilex paraguariensis) on metabolic
    syndrome in TSOD mice.Phytomedicine. 2011 Dec 15;19(1):88-97. Epub 2011 Oct 22.
  27. Stefani ED, Moore M, Aune D, Deneo-Pellegrini H, Ronco AL, Boffetta P, Correa P,
    Acosta G, Mendilaharsu M, Luaces ME, Silva C, Landó G.Maté consumption and risk of cancer: a multi-site case-control study in Uruguay. Asian Pac J Cancer Prv 1;12(4):1089-93.
  28. Rivelli DP, Almeida RL, Ropke CD, Barros SB. Hydrolysis influence on
    phytochemical composition, antioxidant activity, plasma concentration, and tissue distribution of hydroethanolic Ilex paraguariensis extract components.J Agric Food Chem. 2011 Aug 24;59(16):8901-7. Epub 2011 Aug 2
  29. Puangpraphant S, Berhow MA, Vermillion K, Potts G, Gonzalez de Mejia E.
    Dicaffeoylquinic acids in Yerba mate (Ilex paraguariensis St. Hilaire) inhibit NF-κB
    nucleus translocation in macrophages and induce apoptosis by activating caspases-8 and -3 in human colon cancer cells.Mol Nutr Food Res. 2011 Oct;55(10):1509-22. doi: 10.1002/mnfr.201100128. Epub 2011 Jun 8.
  30. Coentrão Pde A, Teixeira VL, Netto AD.Antioxidant activity of polyphenols from
    green and toasted mate tea.Nat Prod Commun. 2011 May;6(5):651-6.Coentrão Pde A,Teixeira VL, Netto AD.Antioxidant activity of polyphenols from green and toasted mate tea.
  31. Silva RD, Bueno AL, Gallon CW, Gomes LF, Kaiser S, Pavei C, Ortega GG, Kucharski LC, Jahn MP The effect of aqueous extract of gross and commercial yerba mate (Ilex paraguariensis) on intra- abdominal and epididymal fat and glucose levels in male Wistar ratsFitoterapia. 2011 Sep;82(6):818-Epub 2011 May 1
  32.  Arçari DP, Bartchewsky W Jr, dos Santos TW, Oliveira KA, DeOliveira CC, Gotardo
    ÉM, Pedrazzoli J Jr, Gambero A, Ferraz LF, Carvalho Pde O, Ribeiro ML. Antiinflammatory effects of yerba maté extract (Ilex paraguariensis) ameliorate insulin resistance in mice with high fat diet-induced obesity.Mol Cell Endocrinol. 2011 Mar 30;335(2):110-5. Epub 2011 Jan 14.Anti-inflammatory effects of yerba maté extract (Ilex paraguariensis) ameliorate insulin resistance in mice with high fat diet induced obesity.
  33.  Am J Chin Med. 2012;40(4):735-52. doi: 10.1142/S0192415X12500553. Eucommia leaf extract (ELE) prevents OVX-induced osteoporosis and obesity in rats. Zhang W, Fujikawa T, Mizuno K, Ishida T, Ooi K, Hirata T, Wada A.
  34. Kwon SH, Kim MJ, Ma SX, You IJ, Hwang JY, Oh JH, Kim SY, Kim HC, Lee SY,
    Jang CG.Eucommia ulmoides Oliv. Bark. protects against hydrogen peroxide-induced neuronal cell death in SH-SY5Y cells. J Ethnopharmacol. 2012 Jul 13;142(2):337-45. doi: 10.1016/j.jep.2012.04.010. Epub 2012 May 14.
  35.  Fujikawa T, Hirata T, Wada A, Kawamura N, Yamaguchi Y, Fujimura K, Ueda T,
    Yurugi Y, Soya H, Nishibe S Chronic administration of Eucommia leaf stimulates
    metabolic function of rats across several organs. Br J Nutr. 2010 Dec;104(12):1868- 77. doi: 10.1017/S0007114510002965. Epub 2010 Aug
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    hypertriglyceridaemic rats. J Sci Food Agric. 2012 Jan 30;92(2):358-65. doi:
    10.1002/jsfa.4586. Epub 2011 Aug 4.
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    protects against renal injury in cadmium-challenged rats.Med Food. 2012
    Mar;15(3):307-14. doi: 10.1089/jmf.2011.1756. Epub 2011 Dec 19.Eucommia
    ulmoides bark protects against renal injury in cadmium-challenged rats..
  39. Kobayashi Y, Hiroi T, Araki M, Hirokawa T, Miyazawa M, Aoki N, Kojima T, Ohsawa T.Facilitative effects of Eucommia ulmoides on fatty acid oxidation in
    hypertriglyceridaemic rats.J Sci Food Agric. 2012 Jan 30;92(2):358-65. doi:10.1002/jsfa.4586. Epub 2011 Aug 4.
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  41. Fujikawa T, Hirata T, Wada A, Kawamura N, Yamaguchi Y, Fujimura K, Ueda T,
    Yurugi Y, Soya H, Nishibe S. Chronic administration of Eucommia leaf stimulates
    metabolic function of rats across several organs.Br J Nutr. 2010 Dec;104(12):1868- 77. doi: 10.1017/S0007114510002965. Epub 2010 Aug 9.
  42. Horii Y, Tanida M, Shen J, Hirata T, Kawamura N, Wada A, Nagai K. Effects of
    Eucommia leaf extracts on autonomic nerves, body temperature, lipolysis, food
    intake, and body weight. Neurosci Lett. 2010 Aug 2;479(3):181-6. doi:
    10.1016/j.neulet.2010.05.030. Epub 2010 May 16.
  43. Jin X, Amitani K, Zamami Y, Takatori S, Hobara N, Kawamura N, Hirata T, Wada A,
    Kitamura Y, Kawasaki H. Ameliorative effect of Eucommia ulmoides Oliv. leaves
    extract (ELE) on insulin resistance and abnormal perivascular innervation in fructose-drinking rats. J Ethnopharmacol. 2010 Apr 21;128(3):672-8. doi:
    10.1016/j.jep.2010.02.019. Epub 2010 Feb 26.
  44. Luo J, Tian C, Xu J, Sun Y Studies on the antioxidant activity and phenolic
    compounds of enzymeassisted water extracts from Du-zhong (Eucommia ulmoides Oliv.) leaves.Enzyme Inhib Med Chem. 2009 Dec;24(6):1280-7. doi:
    10.3109/14756360902829741..
  45. Choi MS, Jung UJ, Kim HJ, Do GM, Jeon SM, Kim MJ, Lee MK Du-zhong
    (Eucommia ulmoides Oliver) leaf extract mediates hypolipidemic action in hamsters fed a high-fat diet Am J Chin Med. 2008;36(1):81-93
  46. Jiang J, Kai G, Cao X, Chen F, He D, Liu Q. Molecular cloning of a HMG-CoA
    reductase gene from Eucommia ulmoides Oliver. Biosci Rep. 2006 Apr;26(2):171-81.
  47. Li Y, Koike K, Che Q, Yamaguchi M, Takahashi S Changes in lactate dehydrogenase and 3- hydroxyacetyl-CoA dehydrogenase activities in rat skeletal muscle by the administration of Eucommia ulmoides OLIVER leaf with spontaneous runningtraining. Biol Pharm Bull. 1999 Sep;22(9):941-6..
  48. Chem Pharm Bull (Tokyo). 1988 Jan;36(1):435-9. Inhibition of adenosine 3′,5′-cyclic monophosphate phosphodiesterase by lignan glucosides of Eucommia bark. Deyama T, Nishibe S, Kitagawa S, Ogihara Y, Takeda T, Ohmoto T, Nikaido T, Sankawa U.
  49. Lee MJ, Rao YK, Chen K, Lee YC, Tzeng YM.Effect of flavonol glycosides from
    Cinnamomum osmophloeum leaves on adiponectin secretion and phosphorylation of insulin receptor-beta in 3T3-L1 adipocytes. J Ethnopharmacol. 2009 Oct
    29;126(1):79-85. doi: 10.1016/j.jep.2009.08.006. Epub 2009 Aug 12.
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  51. Vijayakumar RS, Nalini N.J Piperine, an active principle from Piper nigrum,
    modulates hormonal and apo lipoprotein profiles in hyperlipidemic rats. Basic Clin Physiol Pharmacol. 2006;17(2):71-86.
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    Huang SA, Bianco AC. The small polyphenolic molecule kaempferol increases cellular energy expenditure and thyroid hormone activation.Diabetes. 2007 Mar;56(3):767-76.
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    regulation of adipogenesis by kaempferol, a component of Rhizoma Polygonati
    falcatum in 3T3-L1 cells Biol Pharm Bull. 2012;35(9):1525-33.
  56. Byun MR, Jeong H, Bae SJ, Kim AR, Hwang ES, Hong JH.TAZ is required for the
    osteogenic and anti-adipogenic activities of kaempferol.Bone. 2012 Jan;50(1):364-72. doi: 10.1016/j.bone.2011.10.035. Epub 2011 Nov 12.
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Alpha Mars – 

  1. Shawn M Talbott et al. Effect of Tongkat Ali on stress hormones and psychological mood state in moderately stressed subjects. Journal of the International Society of Sports Nutrition 2013, 10:28
  2. Wilson E Review on shilajit used in traditional Indian medicine.J Ethnopharmacol. 2011 Jun 14;136(1):1-9. doi: 10.1016/j.jep.2011.04.033. Epub 2011 Apr 20.
  3. Stohs SJ. Safety and efficacy of shilajit (mumie, moomiyo). Phytother Res. 2014
    Apr;28(4):475-9. doi: 10.1002/ptr.5018. Epub 2013 Jun 3.
  4. Velmurugan C. Evaluation of safety profile of black shilajit after 91 days repeated administration in rats. Asian Pac J Trop Biomed. 2012 Mar;2(3):210-4. doi: 10.1016/S2221-1691(12)60043-4.
  5. Agarwal SP Shilajit: a review. Phytother Res. 2007 May;21(5):401-5.
    Schepetkin IA1J Characterization and biological activities of humic substances from mumie. Agric Food Chem. 2003 Aug 27;51(18):5245-54.
  6. Mao Z Molecules. Natural dibenzo-α-pyrones and their bioactivities. 2014 Apr
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