Summary:

1. AMPK activation is proportional to ATP availability. As ATP is depleted through fasting and exercise AMPK is activated to tell the body to stop using ATP to make and build and repair things and start burning whatever fuel is available to make more ATP. Very powerful ignition switch to trigger oxidation (burning) of whatever fuel is available to replenish ATP.

By controlling macronutrients and interacting with certain receptors in the body it is possible to use this to significantly increase fat burning and fat loss.

2. AMPK inhibits mTOR pathways that induce protein synthesis for muscle growth and hypertrophy!! It is a burner not a builder!

But again it is all about strategy. AMPK cannot and will not be activated by any supplement or exercise if there is not a deficiency of ATP and if there is an abundance of calories from the macronutrients. Therefore by using supplementation to maximise ATP production and resynthesis e.g. creatine and using proteins, BCAA, EAA plus or minus carbs you cannot activate AMPK and you will instead activate mTOR pathways for protein synthesis.

3. AMP-V ATP Science can be used as a preworkout for both scenarios and maintenance. 

Cutting – For fat loss when combined with calorie deficit and depletion of glycogen and ATP the AMP-V works via modulation of the PPAR receptors with essential fatty acids and enhancing AMPK activation. Post workout stay depleted and you burn for longer.

Bulking – For muscle hypertrophy use AMP-V as a preworkout and maintain adequate or a surplus of  nutrition and calories in the form of protein and carbohydrates than you will get the performance enhancing effects, the mental clarity, the PPAR modulation but not the AMPK activation that inhibits mTOR pathways for protein synthesis. Post workout load up and stimulate growth.

Maintenance – The middle ground which is best for a bit of each involves using the AMP-V for fasted exercise and then replenishing after exercise to stimulate protein synthesis and recovery. Keep you with a bit of each. Most people will find this works for them. The athletes that run on bulking and cutting campaigns that need to create extreme change will do the more strategic cycles.

Hahahaha Matt was wrong and #Jeff was right!! It takes a couple of minutes to replenish ATP not 30 seconds! What a goose Matt is hahahaha


Recommended reading:

Sasaki S1, Nakae S, Ebine N, Aoi W, Higashi A, Ishii K. The effect of the timing of meal intake on energy metabolism during moderate exercise. J Nutr Sci Vitaminol (Tokyo). 2014;60(1):28-34.

Karen Van Proeyen et al. Training in the fasted state improves glucose tolerance during fat-rich diet Physiol 588.21 (2010) pp 4289–4302 4289

Makanae Y1, Fujita S. Role of Exercise and Nutrition in the Prevention of Sarcopenia. J Nutr Sci Vitaminol (Tokyo). 2015;61 Suppl:S125-7. doi: 10.3177/jnsv.61.S125.

Meamarbashi A1, Rajabi A. The effects of peppermint on exercise performance. J Int Soc Sports Nutr. 2013 Mar 21;10(1):15. doi: 10.1186/1550-2783-10-15.

Meamarbashi A1. Instant effects of peppermint essential oil on the physiological parameters and exercise performance. Avicenna J Phytomed. 2014 Jan;4(1):72-8.

Tan XC, Chua KH, Ravishankar Ram M, Kuppusamy UR. Monoterpenes: Novel insights into their biological effects and roles on glucose uptake and lipid metabolism in 3T3-L1 adipocytes. Food Chem. 2016 Apr 1;196:242-50. doi: 10.1016/j.foodchem.2015.09.042. Epub 2015 Sep 12.

Van Proeyen K, Szlufcik K, Nielens H, Pelgrim K, Deldicque L, Hesselink M, Van Veldhoven PP, Hespel P. Training in the fasted state improves glucose tolerance during fat-rich diet. J Physiol. 2010 Nov 1;588(Pt 21):4289-302. doi: 10.1113/jphysiol.2010.196493.

Iwayama K, Kurihara R, Nabekura Y, Kawabuchi R, Park I, Kobayashi M, Ogata H, Kayaba M, Satoh M, Tokuyama K. Exercise Increases 24-h Fat Oxidation Only When It Is Performed Before Breakfast. EBioMedicine. 2015 Oct 30;2(12):2003-9. doi: 10.1016/j.ebiom.2015.10.029. eCollection 2015.

Sasaki S1, Nakae S, Ebine N, Aoi W, Higashi A, Ishii K. The effect of the timing of meal intake on energy metabolism during moderate exercise. J Nutr Sci Vitaminol (Tokyo). 2014;60(1):28-34.

Figueiredo VC1, Cameron-Smith D.Is carbohydrate needed to further stimulate muscle protein synthesis/hypertrophy following resistance exercise? J Int Soc Sports Nutr. 2013 Sep 25;10(1):42. doi: 10.1186/1550-2783-10-42.

Staples AW1, Burd NA, West DW, Currie KD, Atherton PJ, Moore DR, Rennie MJ, Macdonald MJ, Baker SK, Phillips SM. Carbohydrate does not augment exercise-induced protein accretion versus protein alone. Med Sci Sports Exerc. 2011 Jul;43(7):1154-61. doi: 10.1249/MSS.0b013e31820751cb.

Koopman R, Beelen M, Stellingwerff T, Pennings B, Saris WH, Kies AK, Kuipers H, Van Loon LJ. Coingestion of carbohydrate with protein does not further augment postexercise muscle protein synthesis. Am J Physiol Endocrinol Metab. 2007;293(3):E833–842. doi: 10.1152/ajpendo.00135.2007.