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Episode 47 – PPAR Modulators

Transcript

Introduction:
Welcome to the ATP Project Episode 47 – PPAR.
In today’s podcast Matt and I continue our discussion on Upregulating Receptors to enhance Fat Burning.
• Overuse of MCT Oils can turn off Fat Burning.
• Release of new ATP Science product set for launch at this year’s Arnold Classic in Australia.
• FAQs.
Stay tuned, the ATP Project is about to start.

Welcome to the ATP Project, you’re with your hosts Matt and Jeff.

Jeff: Matty?

Matt: G’day.

Jeff: PPAR.

Matt: What did you call me?

Jeff: We’re talking about Fat Burning a lot at the moment.

Matt: Yes.

Jeff: And, it seems that we talk about one topic and then that leads to another one. So, we spoke about the Liver impact on Fat Burning, we spoke about AMPK food timing, Hepatothermic—there you go, I’ve got it.

Matt: You got it.

Jeff: There are lots of moving parts with regards to Fat Burning, and when I think we’ve finally finished and we can move on to something else, we always get talking and there’s something interesting that you mention.

Matt: Yeah, I know.

Jeff: PPAR.

Matt: Yeah.

Jeff: So, what is PPAR?

Matt: Well, I just like stirring you up, but basically we’ve been talking about all these cool ways of stimulating Fat Burning and I’ve kind of explained that the generals behind the whole system are these PPAR Receptors. Now, we’ve got this particular group of Receptors in our body that sensors, they’re picking up on what fuel is available, so we’ve got these little sensors in our body that can determine if we’re starving or they can tell us if we’ve got an abundance of any fuel, and what they will do is they will control a bit of the hierarchy and say, “We have to Burn Fat now,” or, “We have to Burn Sugar now,” or whatever. So, there are all these cool things you can do with Nutrients and Herbs and everything like that, but at the end of the day, if we don’t have the permission from the PPAR Receptor Group to actually force the body to Burn Fat then it’s not going to happen.

So, once you understand that sort of knowledge that we’ve got to ask permission from these things first, or control their priorities, it actually leads us into a whole other train of thought which is, “Well how can we screw with this system? Are there ways of actually priming up these PPAR Receptors to encourage the body to Burn a particular fuel?

Jeff: Where are these PPAR Receptors, Matt?

Matt: Everywhere. There are three main classes of PPAR Receptors, but they’re found on pretty much every cell of our body, so all the way through the Intestinal Tract, through the Liver, and they’re the main driving forces behind a lot of that Hepatothermic stuff we talked about, but they are everywhere. And, they have different roles, so they’ve got specific roles in amongst the PPAR Receptors where some of them will be activated during Fasting and say, “At this stage stop storing everything, there is nothing to be stored. Let’s Burn, Burn, Burn.”
There are other ones that are activated with an abundance of Calories or an abundance of a particular Fat or Sugar, and say, “Let’s store. We need to increase the amount of Vesicles that we’ve got to store things, so we’re going to make new Fat cells to store more Fat in,” or, “We’re going to make more Fat cells and take some of this Sugar and make it into Fat and store it over here.”
Then, we’ve got other PPAR Receptors that regulate—“What are we seeing more of? Are we Burning Sugar or are we Burning Fat, or we’ve got a balanced diet and we’re doing a little bit of each.”
So, screwing around with the PPAR Receptors is a really good way of priming our body to get ready to Burn for a particular fuel source. And, then when we have the PPAR Receptors already pre primed, then if we go through and activate the actual driving forces or use the—what’s an example? Everyone talks about Catecholamines, you know, Adrenaline, Noradrenaline—so, once we’ve got PPAR primed to say, “Fat is our preferred source of fuel, that we are in the process of Burning Fat right now.” If we prime up that and then go through and tweak the other driving factors behind Fat Burning, then you can get exaggerated results.

If you are there hitting all these other targets trying to say, “Force Fat Burning, Force Fat Burning,” but PPAR is not playing the game, PPAR is basically saying, “Hang on, you’ve got massive amounts of oil available, we’re not going to Burn this, we’re going to start storing Fat.” Or, “We’ve got massive amounts of Sugar available, we can’t go and Burn Fat off your hips, we’ve got to process this Sugar first.” If you haven’t coordinated that hierarchy within the PPAR Receptors family then everything else you’re doing they kind of work, but…

Jeff: You’re going uphill?

Matt: Yeah, there’s a bit of a handbrake on things already, and it might only be a temporary handbrake until we push these things hard enough, but we’re looking at small windows of opportunity to train and get the most out of that as we possibly can and spend the rest of the day in a Depleted State or whatever. So, we don’t really want any handbrakes. The difference between the prime athletes and the guys that are struggling is their ability to remove handbrakes, not their ability to push harder, it’s their ability to go through and say, “Hey, this is holding me back and I’m going to eliminate that from my life or my protocol.”

So, that’s a big thing, we’re getting a little bit smarter with the way we work. While I’m saying that, I’ve been doing a lot of research on these foods and things like sweeteners and Insulin and types of Fats and everything, and there is a massive difference between what happens in a trained healthy person with a good body that doesn’t have Insulin Resistance because they’re an athlete, there’s a massive difference between what happens to those people and what happens to someone that’s not consistently training, that doesn’t have a really good Muscle Fat ratio, that may be slightly overweight, obese. And, crazy overweight obese, of course, are going to be weird. But, there is a big difference between someone that’s not fit, trained, and in a regular process of depleting energy stores and reloading and how they respond to Artificial Sweeteners, and how they respond to Sugars and things like that, compared to a trained athlete that’s maybe even an enhanced athlete, the way Insulin and Sweeteners, and the way things like that work with a Personal Trainer or an athlete might be totally different to the way they work with the average person that’s working underneath those people.

So, there are a lot of assumptions being made, “What works for me, as an athlete—and, I’m pretending I’m an athlete here—and this is what I’m saying that a lot of the PTs and a lot of the athletes may be saying to their customers, “What works for me is this. I am fine to be able to consume bulk amounts of protein and sweeteners and all that stuff, and it doesn’t affect my body so therefore you’ll be the same.” There’s a massive difference between someone that’s fit, healthy, and even trains regularly, compared to someone else that’s hit and miss with their training and not in the ideal Body Fat Muscle Mass range.

Jeff: But, even with that, Matt, I guess you could say that even for the high end athletes that are really good, that can handle that more, they still do better if they remove that.

Matt: Yeah, exactly. It’s still happening. You said it yourself, they can handle it better. It doesn’t mean it’s not happening, they can just handle those things better, it’s more of a temporary thing, it’s less of a roadblock, less of a hurdle.

Jeff: It’s interesting. Working with people like Chris Thomas, and Metabolic Profiling, so they look at certain areas of the body, having certain different Hormonal Profiles, Estrogen Dominance, too much Cortisol production or what have you, which is smart. I think that’s a good way to be able to attack something because everybody is different. You can say there’s commonalities, and that’s the thing, how do you find broad strokes, Matt, for the average person out there?

Matt: Well, this is why I’m looking at PPAR things.

Jeff: That’s right. So, if we can push that handle, no matter whether you’re a highly trained athlete or whether you’re someone who’s just getting into it, everyone wants to maximise their effort; maximise the results they’re going to get from whatever changed they’re making to their diet, whether they’re eating eight meals a day, perfectly weighed out ratios and everything, or whether they’re just going, “You know what, I’m just going to eat the old handful, the fistful, I’m going to eat more regular, I’m just going to reduce my sugars. Everybody’s got different things that are important to them, so long as they’re making an effort to reduce calories, to increase exercise, to lower sugars…

Matt: Make a change.

Jeff: Make a positive change, but then utilising training and/or supplements and getting advice to maximise results from that, because that’s what everybody wants.

Matt: Like I’m saying, with these small windows of opportunity that the average person’s got to train they want to maximise it and want to know that they’re not wasting time. You also want to know that you’re not doing more harm than good, because a big thing that athletes will always say is, “Trust the process, you’ve got to trust the process,” and a lot of people out there don’t trust the process because the process worked for someone else but it hasn’t worked for them. So, what we need to do is get a plan that is thought out and smart and start with that and then tweak it as you go.

So, back to your original question, “What are PPAR?” PPAR Receptors are little antennas that live on the cells of our body and they measure what’s available, what fuel source is available. So, based on the availability of types of fuels they can determine whether you’re in a fasted state or not. So, you can manipulate PPAR Receptors with supplements, but really the big stuff is the foods, they type of foods that’s available, because they’re antennas, they’re picking up signals from the bloodstream so you need decent doses of these things to be able to interact them enough to think, “This person is eating this available fuel supply,” or, “Not eating this available fuel supply.”

Basically, the more research I’ve done onto these PPAR Receptors is, basically, if you’re in a Fasted State, so if you haven’t eaten for four hours, all your Insulin and everything has dropped off, and they’re the signals that PPAR uses to determine if there is sugar there. So, if all of these things are giving an indication to PPAR that you’ve actually got no more available fuel coming through, you’re in a fasted state, certain PPAR Receptors that are involved in breaking down fuel to fuel your energy requirements are up-regulated. The PPAR Receptors that are there to store that fuel and make new Fat Cells are all switched off, all because you haven’t eaten for a certain period of time and the body says, “Right, let’s switch over to Fat Burning.”

Jeff: But, it’s not just Fat Burning. Obviously, I’m thinking, in the back of my mind, you could also look at up-regulating Catabolic activity for the muscle tissue as well; that’s a trick, Matt.

Matt: Yeah, but the funny thing with PPAR they’re predominantly revolving around Sugar and Fat, so even with Proteins and things like that they have to fit into the Sugar or Fat, meaning that if your Sugar is inadequate and it’s insisting the PPARs are saying, “No, you’ve got to Burn Sugar—so, for example; you might be in a Fasted State, the PPARs that Burn Fat have been up-regulated because you’re in a Fasted State and it’s decided it has to start Burning Fat from your body. The PPARs that tell the body to store Fat they’re all switched off. The PPARs that actually work on storing Carbohydrates as Fat, or Burning Carbohydrates as a source of fuel, are actually modulated and say, “Just hold on, we’re not sure what’s happening with Carbs.”

So, you wake up with your PPARs adapted to the fact that you haven’t eaten for a while and they’re telling your body to prime for Fat Burning. If the next thing that crosses your lips tells your PPAR Receptors that there’s something other than Fat available then all of sudden those PPARs start changing, basically saying, “Okay, we’ve had signals coming through from our Olfactory senses, we’re smelling that we’re making food, we’re seeing colours,” so all these things are coming through suggesting there’s a type of food coming through and then it may secrete Insulins and that if it’s Carbohydrate based or if it’s got a sweetener or something. That tells your body that, “Hey, there’s other fuel coming through, you don’t need to keep Burning, Burning, Burning all the time, let’s just modulate these PPARs again, start up regulating these ones that are preparing to store some of this stuff if it’s too much, start up-regulating these ones that are going to make Insulin work better to take some of that Sugar inside the cells, and just put a handbrake on those ones that are Burning Fat because we don’t know what fuel is coming in next, and we may not need to tap into our reserves if it’s basically full of Carbohydrates.”

Alternatively, you get up in the morning, the PPARs that are encouraging the body to Burn Fat, they’re primed, the ones for the Sugar, they’re saying, “Just stay on hold, we’re not sure what’s coming through,” the ones saying store and put all this extra into Fat are all switched off. If we then coat our tongue with a Fat, particular types of therapeutic Fats that tell the body that there is no Sugar coming, it’s all Fat, you’ve already primed for Fat Burning. Then we put in these particular Fats that interact with PPARs in a very specific way to tell the body, “Man, we have to Burn Fat, we’ve got to keep burning Fat.” Then what happens is, all the other Enzymes involved in Fat Burning are already primed, they’re already ready to go. So, basically, you’ve got two lots of machinery, one can Burn Fat and one can Burn Sugar, and the fact that you’ve been Fasting for a period of time means that it’s upregulated the one that’s going to Burn Fat and put away the machinery to Burn Sugar.

Jeff: It’s easier to get that…

Matt: Yeah, so it’s already primed, and then all we’ve got to do is to trick the body into thinking there’s an abundance of Fat, not only, “We’ve got to Burn,” but, “We’ve got to Burn faster.”

Jeff: I know, Matt, that some people talk about MCTs, and it’s funny, because I remember I used to sell quite a lot of them. A lot of people were on the Atkins Diet and the Ketogenic Diets used to come in and grab MCTs because the Medium Chain Triglycerides, meaning that it’s easier for these things to Burn Fat, and a lot of people now, who are using Fasted Cardio, are starting to get a bit smarter about it and they’re starting to prime by taking a little bit of MCT. A good idea or bad idea?

Matt: MCT is a weird one. The benefit of MCT compared to the other—MCT is not a big PPAR modulated. So, for starters, MCT’s got bugger all to do with PPAR. MCTs are a very simple molecule, they’re very easily dissolved, they’re very easily processed through your Digestive Tract, which also means they’re very easily absorbed and very quickly absorbed out of the Stomach and the top part of the Duodenum, the Small Intestine, and they go through the Portal Vein and they go straight to the Liver, and then the Liver has the ability to them palm it through the Ketogenic processes, so the Liver then will quickly absorb the MCT. They’re basically a quick and easy—they’re an alternative fuel supply to the longer chains that you’ll get from other dietary Fat.
So, long chain Polyunsaturated Fatty Acids, they’re the ones that interact with the PPARs, they’re the ones that often go through, so CLAs, and Conjugated Linolenic Acid, all the Conjugated Fatty Acids, they interact with PPARs more. MCT is kind of a sneaky way of quickly providing a very fast energy source that makes Ketones. It predominantly goes down the Ketogenic Pathway. What happens with MCT is, the Liver predominantly burns them, and it makes Ketones and the body then uses the Ketones as a source of fuel. The problem is, the doses of MCT they typically use is enough to fuel the whole exercise, so they’re basically giving MCT and saying, “Use this to spare your Glycogen,” or, “Use this to spare your Body Fat,” they’re basically saying, “Use this instead of using anything from within your body and use this MCT instead of using Sugar.” So, basically, priming with MCT is not so much priming with MCT, it’s giving your body an alternative fuel supply.

The reason why it’s good is because it’s a Fat, and so the fact that it is a Fat means it won’t switch off Fat Burning, it will fuel Fat Burning. Does that make sense?

Jeff: Yeah.

Matt: But, it’s fuelling Fat Burning from outside, so you’re drinking something that your body is then going to Burn, and it’s all to do with dose, a little bit of MCT—so, what you want to do…

Jeff: Yeah, that’s what I was going to ask, what happens if you use just a small amount?

Matt: Seriously, what you need to do is, you need to create—and, you only need a little bit to prime these things, you’re basically tricking the body into thinking, “We’ve got available Fat, a small amount of available Fat, not enough to encourage the body to up-regulate its ability to store Fat.

Jeff: That’s the trick?

Matt: Yeah. Because, if we put in too much the PPAR Receptors that are telling your body to make new Fat Cells and hold this excessive Fat in as Fat Cells. Okay? Now, my concerns with high doses of MCT as a primer—well, the traditional stuff came from people who were doing Ketogenic Diets and they’re thinking, “How do we get more Ketones made without being strict on their diets?” They can throw MCTs in and you quickly make Ketones, and that was good for the Epileptic and the seizure kids. Then they did all that endurance stuff where they had all the cyclists and everything like that, they were using a Ketogenic style diet to starve the Muscle Cell of Carbohydrate to increase the amount of Mitochondria they made, so they perform worse and then get tougher.

Jeff: It’s like training without oxygen, you’re training with resistance, almost.

Matt: Yeah, exactly, they’re training with Carbohydrate restriction.

Jeff: So, the body becomes more efficient at getting the Nutrients it needs from Fat?

Matt: And burning fats and that sort of stuff. And, then they throw the Carbs back in and then it’s got all the extra Glycogen plus the ability to drag the Fat through, and they training their body to preserved Glycogen by using MCT as an alternative fuel supply. So, basically, putting in a big dose, anywhere from 20 grams, so a typical dose would be—I’ve never seen anybody do less than 10 grams, which is like two teaspoons, but typically they’re doing up 30, 40, 50, 60 grams of MCT to fuel their exercise. And, that’s what it does, it fuels your exercise.

Jeff: But, you’ve got to be careful when you do that, too. And, you can get green apple splatters if you use too much of that, too, couldn’t you?

Matt: Oh, hell yeah, it will go straight through.

Jeff: Because your machinery once it gets used to that…

Matt: It totally screws with your Gut Flora.

Jeff: Oh really?

Matt: Man, it binds to the good friendly Bacteria and stops them adhering and everything goes straight through, especially the MCT in particular, which is a Capric Acid, Coproic Acid, that’s the part of MCT that’s not saturated, that stays clear, it dissolves well, it’s an interesting one, it disperses well. So, what’s interesting there about the MCTs is, you’re using them instead of using the Fat on your body. You only need about 1 ml of MCT or .5 ml, you only need the tiniest amount of MCT to prime. So, if you’re using MCT as a primer you would only use the tiniest amount, and it would have to be by itself and just coat the tongue. So, MCT a small amount as a primer and trick the body into thinking you’ve only got Fat to Burn but there’s not enough Fat to fuel the exercise so you Burn it and then you move into the Fat off your body. If you do too much the Fat that’s liberated from your body then gets stored, so you may be using the MCT as your source of fuel, and you hear people all the time saying, “It can’t possibly be stored as Fat,” or whatever…

Jeff: Yeah, I used to hear that all the time, it’s ridiculous.

Matt: But, if your Calories aren’t right—so, you’re using that as an alternative to Burning the Fat off your hips, so the Fat on your hips will go to your other bum cheek. The other problem is, one of the other things in our body is the negative feedback from Ketones. If you make a certain amount of Ketones, then it switches off Fat Burning. Diabetics, it must drive them crazy with all these people talking about Ketones because Diabetics know that if they get Ketone Acidosis they can die. If you get too many Ketones you die. So, what happens, the body doesn’t like us dying from Ketones, so typically when you Ketone levels build up it sends a message back to your body saying, “Don’t Burn any more Fat because you’re going to make more Ketones, and we’ve already got too many Ketones.”

Now, the frustrating thing is, those Ketones weren’t made in the MCT group from Burning the Fat off your hips they were made from eating MCT.

Jeff: Right.

Matt: So, the point is, priming up the body to prepare for Fat Burning using a high dose of a Fat, all it does is it gives an alternative energy supply. A little bit of MCT is really cool, because what it does is it goes straight through, and because it’s such a simple small chain Fatty Acid it goes straight in and you Burn it really quickly. So, what it means is, if you’re doing Fasted Cardio and you have a little bit of MCT it gives you quick fast fuel because there’s usually a bit of a backlog in and around your Liver where it’s got a big backlog of these long chain Fats that it’s trying to process to free up the Fatty Acids so the Muscles can Burn them…

Jeff: But, it’s slow, it takes a bit of time for that.

Matt: It takes a little bit of time.

Jeff: So, your body can go over into a Catabolic event?

Matt: Oh no, usually it’s just lethargy, it will kick in, but you’re basically running ATP, running Glycogens and that sort of stuff until they’re completed and this stuff eventually kicks through. But, we often get a bit of a backlog in the Liver, you strip the Fat out of the Muscle really quickly, but the Liver just takes a little bit. So, if you bypass that blockage and use MCT, which goes through a Ketogenic Pathway, makes Ketones, that quickly goes out and fuels the Muscle until the long chain Fatty Acids, but it keeps priming it down that Fatty Acid Oxidation Pathway. So, that’s the cool thing. But, MCT doesn’t do it much through PPAR.

The ones that really do interact with PPAR, your Omega 3 Oils are very powerful for that. You see all the Omega 3 Oils, they talk about controlling Inflammation, Insulin Sensitivity, blah, blah, blah, they do that through PPAR Receptors; PPAR controls Inflammation and also controls the way our body Burns Sugar and Fat. So, therefore the PPAR Receptors regulate Cardiovascular Disease, Diabetes…

Jeff: Cancer.

Matt: Cancer; a massive part of cancer.

Jeff: Can we say that word? Well, I just said it.

Matt: You can say it; just don’t say you cure it. You’re allowed to even say you’ve got it.

Jeff: Right.

Matt: So, basically, that’s the thing. If you look at the three main PPAR subtypes—I’ll try to simplify it because you don’t need to know these things too much because we just show you how to screw with it, you know. PPAR Alpha is the one that the Omega 3 activates predominantly. PPAR Alpha is the most well researched, that probably why it’s got the Alpha name. But yeah, that’s the one that stimulates the release of Fatty Acids for Lipolysis—Lipolysis is the freeing up of Fatty Acids out of Triglycerides that are stored or in transit.

Jeff: So, that gets them into the bloodstream, or in a way that the body can be using it?

Matt: It makes you capable of Burning fat. So, for example, a Triglyceride is three Fatty Acids attached to Glycerol, so what it’s doing is releasing those free Fatty Acids so they can go round and be Burnt of Oxidised.

Jeff: And, that’s the trick, you want to Oxidise them, you don’t want them just floating around?

Matt: No, you don’t want them floating around, and that’s the point, Man, that’s what I’m saying. These things are floating around, so these things have already been up-regulated and floating around, and then if you throw in a massive dose of MCT, you’re going to Burn the MCT. This stuff that’s been liberated and floating around is never going to get Oxidised, and it’s then going to go and interact with the other PPAR Receptors like PPAR Gamma, which controls Adipogenesis, which is the generation of new Fat Cells to store the excess Fat.

Jeff: Wow. So, we want to down regulate that but up-regulate the Alpha.

Matt: Yeah, you want to screw with them. So, you need to modulate them properly and get the right ratio. So, PPAR Alpha, the other thing it does is it’s very powerful for Mitochondrial Density, meaning that if you train consistently—so, if you get up and do Fasted Cardio every day PPAR Alpha knows you’re doing that, so PPAR Alpha gets activated every day through Fasted Cardio, and every day it’s sending a message there saying, “We need to get better at Burning Fat for fuel because we’re doing this exercise consistently.” One of the adaptations the body makes to Fasted Cardio is increasing PPAR Alpha activity, which tells the body to get better at Burning Fat for fuel. Part of that is, you’ve got to get better at releasing the Fat out of storage, that’s one. You’ve got to get better at…

Jeff: Lipolysis.

Matt: You’ve got to get better at delivering the Oxygen, and that sort of stuff, controlling Circulation, and then you’ve got to get better at making more of the machinery that’s combining the Oxygen and the Fat to make energy, which is the Mitochondria. So, it can actually increase Mitochondrial Biogenesis, tell the body to make more Mitochondria per cell.

Jeff: So, it’s like increasing the furnace, increasing the number of furnaces?

Matt: Exactly. And, Mitochondrial density tells us more about fitness and strength, and that’s why sometimes you can see some body builders there that can look extremely huge but they don’t have the strength or the resilience that you might find in a concreter.

Jeff: An athlete?

Matt: Yeah, a guy that’s all day, every day lifting things and doing that. And, you can see the strength in some of the—and, you’ve seen it with our experience with the Cross Fit and the Strong Man, all those sort of things. But, you can’t just look at someone and say, “Man, you’re going to be strong,” because there’s that Mitochondrial density that…

Jeff: And, that just relates to the function of the Muscle and the way that it’s used.

Matt: Yeah.

Jeff: Alright, Matt. So, that’s PPAR Alpha, PPAR Gamma. What else?

Matt: There’s a PPAR Beta, and it’s a bit harder to find and a bit harder to access, there’s a lot less research on it, but that’s the main one that’s priming us for Fat Burning, and they all also regulate Insulin Sensitivity and that sort of thing as well. So, it’s quite interesting. What we need to do is create a really cool strategy to screw around with the PPAR, but you need to combine it with time of day of eating, time of training, and then what we need to do is screw around with the PPAR Receptors through the Digestive Tract, through the Liver, and then accessing the Muscle and Fat.

The best way to do that is Omega 3 Oils, Omega 6 Oils, we’ve got to get the right combination of Essential Fatty Acids, but the really exciting stuff is the Conjugated Fatty Acids. So, the Conjugated Linoleic Acid, Conjugated Linolenic Acid, Omega 5 Oils like Punicic Acid; these are the things that are showing some really cool research on the ability at a very low dose to manipulate PPAR. But, you’ve got to combine it with the big picture. So, if you’ve got Fats in your bloodstream from your body and we prime those Fats up with other Conjugated Fatty Acids and other unique Fatty Acids that have got very strong affinities for these Receptors then they swish around with the other oils and interact with the Receptors and really have an exaggerated priming effect, to say, “No, we only have oil to Burn, we’re going to continue to Burn Fat, Fat, Fat.” So, remember when we were talking about things like AMPK and that sort of stuff?

Jeff: Yes, that was last week.

Matt: Was it? Cool.

Jeff: I know; it feels like a million years ago.

Matt: With AMPK, AMPK is the master switch that tells our body when our ATP levels are getting low. So, when you first start doing your exercise—and, I think we talked about this in the AMPK episode where initially we’re just Burning ATP.

Jeff: Yeah, the first 10 seconds, and then I think up-regulation.

Matt: Yeah, and then there’s ETP and then you’re stored Creatine will actually go through and help to replenish that ATP, and that’s pretty much what you’re doing for the…

Jeff: The Creatine Phosphate is it?

Matt: No, no, just Creatine Phosphate; the Phosphate Creatine Stores they call it, but it’s different from when we take Creatine. That’s why we take Creatine, load up on Phosphate Creatine inside our Muscles and that gives us the ability—so, we release that electron from the ATP, it makes ADP, and then it actually resynthesises that ATP really quickly.

Jeff: It joins them back together again.

Matt: Joins them back together from our Phosphate Creatine source, that’s what Creatine does, all within that first—between six to 10 seconds of training, that’s what it’s doing. Now, the main thing is, with our hierarchy we’ll Burn that ATP first, and as that ATP declines that’s when AMPK is activated as the master switch to say, “We need to replenish this ATP and we can’t do it anymore within ourselves, we need to start Burning either Sugar or Fat to replenish the ATP. So, you got that?

Jeff: Mm.

Matt: So, basically, AMPK is the master switch to say, “Right, now we’re going to Burn stuff that’s available from our diet. The PPAR will determine which one it Burns. So, AMPK is the one that will come in and say, “Burn, Burn, Burn.” If we’ve primed up PPAR to say our only option to Burn is Fat, and then your AMP gets activated during training you get significantly increased Fatty Acid Oxidation; you Burn so much more Fat.

Jeff: And, this is the after Burn not just the training, Matt, or are we just talking about the training?

Matt: I’m talking about training still at this point.

Jeff: Right.

Matt: So, basically, you can actually switch in to Fat Burning during training if there’s no other available fuel source.

Jeff: And, that will happen after about 16 to 18 seconds, because the first 10 seconds are ATP, and then obviously the…

Matt: No, the whole first, the whole ATP, ADP regenerate, it’s all happening within the first 10 seconds.

Jeff: Yeah, okay.

Matt: And, that’s more of a power thing. So, if you’re looking at—so, for example, what I’m suggesting is, we get up in the morning, we avoid anything that’s going to trick the body into thinking Carbohydrates are coming, so we want to avoid things that have got the mouth feel of starches and fibres and that, we want to avoid that sweetness and that sort of stuff from the sweeteners, and any of that actual calories that come in from Carbohydrates and that sort of stuff is going to screw the whole process. So, get up in the morning, and before you eat anything you’re in Fasted State, that’s when we want to use specific oils to prime the PPAR Receptors to get ready, and then what we want to do is we want to start training. Now, when I say start training we want to just do some exercise, it may be high intensity Cardio, it may be low intensity Cardio, it may be moderate, it doesn’t matter so much with this plan, because the belief that we can only Burn Fat up to a maximum of about 65% exertion, but using this process we can increase that up to about 85% exertion, which means you’ll even be capable of using Fatty Acid Oxidation to fuel high intensity Cardio and that sort of stuff.

Jeff: Is that with regards to the Oxygenation in the blood?

Matt: Yeah. Because we have the ability to deliver the Oxygen, the ability to liberate the free Fatty Acids and make sure that those free Fatty Acids and the Oxygen is available to get you past 65% exertion, up to about 85% exertion.

Jeff: How are you going to do that, Matt, how are you going to increase the amount of Oxygenation or available Oxygen in the blood?

Matt: Well, I’m not allowed to tell you.

Jeff: Alright, well we can leave that for another one. And I know a couple of weeks back we’ve spoken about Oxygenation, and I think Blind Freddy can understand that we’ve got a product coming out which ticks all the boxes here. So, do you want to leave that for next week?

Matt: Yeah, well there’s a lot of different ways. I could throw our way in amongst a few others.

Jeff: And, what’s exciting about this as well, too, some of the unrelated effects.

Matt: Freaky, huh?

Jeff: And, we’ve given this to some of our athletes, including Andrea Miller who lifts for New Zealand, she’s an absolute pocket dynamo in terms of her strength. She was trying to lose weight, wasn’t she, Matt?

Matt: Yeah, well she got told that she had to be in the lower weight class and still lift the same.

Jeff: She had to lose eight kilos.

Matt: Yeah, but that was over 10% of her body weight.

Jeff: Yeah, and she didn’t have that much body Fat.

Matt: No, well no Body Fat, she’s shredded, she looks like a burnt rubber thong, she’s ripped. And so, basically, we had to try to find water weight, but there was no water weight, there was no Fat, so basically, we had to downsize. In order to be able to downsize and maintain the strength we had improve Mitochondrial Density.

Jeff: Which, we believe we did.

Matt: Yeah. And, the freakiest thing was, she hit a personal PB with her first dose. Because, what we do is, we understand if we want to prime the Fat we also need to get that Oxygen in there if you’re going to Burn the Fat. The stuff that we’ve done to deliver that Oxygen into the Cells significantly improves performance and significantly alters Lactate threshold, it changes everything.

Jeff: We’re there, we’ve got a patent on this product as well, so we can really start to talk about it but we just don’t want to go too early. But anyway, all I was going to say though, is in terms of Fat Burning, and there were some other exciting effects because of the Oxygenation in the blood, and because of other factors, Andrea was able to smash out some personal bests at a lower weight.

Matt: Yeah, she dropped off about six or eight kilos, or something like that, and she managed to do 11 New Zealand records with eight personal bests and 100% lifting.

Jeff: So, for guys and girls that are out there and obviously want to lose weight, and I’m talking body Fat, but also still perform at a high level in terms of strength in the gym as well too, Matt, I think we’ve got it covered.

Matt: Oh yeah, but also, the more exciting thing—and I depends on who you are what you find exciting—I spent all that time in a Naturopath Clinic and the hardest thing was trying to get people to trust the process, like I was saying. For the average person results don’t come immediately, significant change is not always noticeable. That’s why we’re telling you to measure things and everything like that, because you can lose inches off your waist and not notice. But, in an athlete…

Jeff: Who knows, who are two kilo…

Matt: …that’s measured, that is taking 27 selfies a day to post them…

Jeff: But, with Andrea…

Matt: She measures everything.

Jeff: Well, not only that, when she’s lifting, Matt, if she improves a lift by a kilo she knows.

Matt: What I want people to know is, if we’ve got a right process that’s healthy, but actually good for you—like, these ingredients—what I’m thinking is, there are a lot of people out there who are getting up and doing their morning walk.

Jeff: Which is great.

Matt: They do it, they need to do it, we all know it’s good for us, and we do it. But, they’re often going to buy a pre-workout that’s designed for a body builder, or they’re not sure what to do, they’re doing Apple Cider Vinegar, they’re doing this, they’re doing that. What they want to know, and this from my experience of people I speak to, they want to know that what they’re doing, over time, is going to make them healthier.
Jeff: Not only work, but is making them healthy.
Matt: When you’re going for these walks most of them are doing it for Cardiovascular health so they don’t have heart attacks later in life. We want to know what you’re doing on your daily effort is actually, gradually over time, going to make you better and better and better. And, the supplements that you’re taking, as part of that, is actually going to make you healthier and healthier. You want to know that gradually you’re going to get better, not gradually you’re going to get worse, and you don’t want to be sitting there thinking, “Is this the right thing for me or is there too many stimulants.” You know what I mean?
Jeff: I totally understand where you’re coming from.
Matt: So, the big point is, and that’s why I really get excited about this PPAR modulation. Do you remember, probably a decade ago or something, everyone was talking about brown Fat and white Fat?
Jeff: Yeah, I do.
Matt: So, we had brown Fat which was Thermogenic and is capable of Burning, and white Fat which was just storage, and then they got confused and thought, “Oh gosh, humans don’t seem to have any brown Fat, so let’s stop talking about it,” and then they went, “Oh no, they do have brown Fat, let’s talk about it again.” But, what’s interesting about it is—it’s true, there are different types of Fat in our body, and this isn’t just Visceral or Subcutaneous, this is everywhere within us, it’s just that we have more of the particular type of brown Fat that Burns in the Visceral Fat and the Subcutaneous Fat is predominantly white.
Jeff: Well, that makes sense. And, there’s Mitochondrial Density in the brown Fat, too right?
Matt: Exactly, and that’s what makes it brown.
Jeff: Right.
Matt: That’s what changes the colour, the amount of Mitochondria within it. So, what’s interesting the PPAR modulation, by activating the PPARs, especially PPAR Alpha that has been shown to stimulate Fat Burning, they have been shown to actually turn white Fat to brown, or speckled brown Fat in amongst the white Fat. So, basically, what I’m saying is…
Jeff: Beige.
Matt: Yeah, that’s why they call it Beige Fat, or Brite, which is brown and white.
Jeff: Oh my Gosh, the scientists came up with that?
Matt: Yeah, so it’s BR from brown and ITE from the white, and its Brite, and so they talk about Brite Cells, which aren’t bright, they’re kind of Beige. But, this is the funny thing about it, the PPAR modulation, over time, so doing the exercise, the daily Fasted Cardio, priming up our PPAR Receptors and that sort of stuff, over time the white dead Fat—and I shouldn’t say dead, but the stuff that’s sitting there and working predominantly as storage and making you look fat and horrid and contributing to heart disease is going to become speckled with beige and brown Fat Cells, become more Thermogenic, make it easier to Burn, and make it better to contribute to your energy levels rather than contributing to your disease and your fatigue.
Jeff: And, the body is efficient, so therefore if the brown Fat is richer in energy, and the body knows that, and again, if the machinery is there it’s more inclined to tap into that brown Fat because the body is always efficient, it will go for the highest level of energy it can get.
Matt: Yeah. So, basically, what happens, we hit a plateau after we Burn off our Visceral Fat, but if you’re converting a lot of Subcutaneous Fat from stagnant white into beige and brown then you’re actually going to be Burning a lot more Fat from the Subcutaneous. But, the cool thing is, is you’ve actually changed your normal. You know I always talk about adaptation and equilibrium, our body wants us to stay the way we are, it wants us to stay as what it thinks is normal because it thinks that’s our healthy survival bit.
Jeff: So, change what’s normal.
Matt: That’s the point. We’re constantly adapting to bring back to normal, so what if we’re working on a plan to change what your normal is? And, the other thing, while we’re talking about that point, one of the most frustrating things that I used to hear in the clinic all the time, and I still hear it all the time from people that are doing a Fat Loss campaign, is that they’re all down in the dumps thinking, “I can never not be a Fat person, because I’ve made these Fat Cells, these Fat Cells never go, they just shrink and the refill.”
Jeff: Well, yoyo dieting, classic, Matt.
Matt: Yeah. So, everyone’s is out there saying, “Okay, you’re always going to be Fat, you’ve just shrunken your Fat Cells and they’re going to puff back up again.”
Jeff: As soon as you take a teaspoon of sugar or a chocolate…
Matt: So, that’s planted in their brain, they don’t believe they’re ever going to be a different person, they believe they’ve created this reality and they’re stuck with it. What people need to be saying is, “Hey, these good things you’ve done to get lean, if you keep doing them you’ll stay lean and get leaner. Those bad things you did to get Fat, if you do them again you’re going to get Fat,” so that’s pretty obvious, eh?
Jeff: Yeah, that’s fair enough.
Matt: But, what I’m excited about is some really cool research for Fat Apoptosis.
Jeff: Now, this is going back—when we first started the company we spoke about this, do you remember?
Matt: My Fat Bong, yeah.
Jeff: Your Fat Bong. Matt never names any products, no; INFRARED would have been Red Dog.
Matt: So, now you’ve got Hepatothermic sorted out you’ve got to learn Adipocyte Apoptosis.
Jeff: Alright, well teach us, Matt, what’s that?
Matt: I just said it. Adipocyte Apoptosis. That’s why I call it Fat Apoptosis. But, basically, there are self-destruct genes in every cell of our body. Do you know there are genes within our Fat Cells that will tell them to self-destruct? I need everyone to know that Fat Cells don’t necessarily just grow, shrink, stay there waiting to be filled up and then you make new Fat Cells, it’s not just a constantly ever expanding mass of Fat Cells. There are cells in our body—not just Fat Cells, let’s just talk about cells in general—when we divide cells, if they’re defective, if they’re mutant weirdos like cancers and that, if they’re empty and useless, if they’re extinct, or expired might be a better word, then the self-destruct gene is activated and those cells are destroyed. Fat Cells have those same genes just like cancer cells and every other cell of our body has.
So, interestingly, these same ingredients that work on the PPAR Receptors also work on the genes that regulate Fat Apoptosis. Apoptosis just means self-destruct; I just think it sounds cool. So, what’s important to know is, if we’re doing it on a plan—imagine this, if you were getting up and doing your morning walk that you’ve been doing every day for the rest of your life and you’re going to be doing it forever, and you’re going to encourage the rest of your family to come with you, if you’re doing something that is priming up for Fat Burning so you enhance the amount of Fat you’re Burning, and it’s also controlling Inflammatory processes, also improving Insulin Sensitivity, it’s also doing those sorts of things. But, over a long period of time it’s working on the conversion of your white Fat to brown Fat, changing who you are. As it’s infiltrating into the tissue any cells that are abnormal, that aren’t necessary anymore, those Fat Cells that the body’s forgotten are there, whatever, they can activate self-destruct genes. Over time you’re creating a new normal of what you are.
Jeff: And, the body, Matt, as you say, naturally has these, and correct if I’m wrong, but we were talking about bringing this product out, which was four years ago but it never made it into production because there wasn’t enough demand for it. The nice thing though, this new product that we’re bringing out combines a hell of a lot of benefits into one product; an amazing amount.
Matt: It’s freaky.
Jeff: But, the body will self-destruct the Fat Cell if it lies dormant for a period of time. Is that correct?
Matt: Yeah, that’s true.
Jeff: So, over time, again, the new norm…
Matt: I saw a classic picture the other day, someone wrote up one of those things, Memes, and it said, “I wish I was as Fat as I was the first time I thought I was Fat,” and I thought, “Oh yeah, that’s clever, because it’s quite funny, and I don’t know if you’ve noticed, but my Fat weight might be 90 kilos, and these are just numbers I’m picking out, that’s actually my lean weight. So, you might say my Fat weight is 90 kilos, and the funny thing is, you might lose a bit, you might lose two or three kilos under that, you might put on two or three kilos over that, but you keep hovering back to that 90 kilos, so when you’re doing everything right you’ll sit at 90 kilos. But, when you ate the rubbish food and you went up to 93 kilos, 94 kilos, if you just hold that for about three months your new set point weight then is about 93 kilos.
Then, what happens, the same thing happens, you’re hovering around, and the next thing you know, “Oh yeah, I’m hovering around 95 kilos, that’s my set point weight.” Next thing your set point weight just goes up to 100 kilos.
Every time you hold a particular weight or a particular body shape for a period of three months it seems to become your new set point weight, and the same thing happens in reverse order. So, if you drop down and you hold that weight, maintain that weight for a certain period of time it becomes your new set point weight where you can hover around that weight instead of the next weight. That’s why it’s cool to do stints and work on a campaign, and the point is to try and hold that for three months.
Jeff: Well, I think I’ve mentioned this analogy before, when I used to do martial arts, a lot of the guys that get their black belt have pretty much all quit. Now, the whole idea of the black belt was, that actually meant a way of life. And, it’s funny, I think a lot of people do these—and, not everyone, obviously there are some serious [0:45:44] out there where it is their way of life, but I’m talking about the fly-by-nighter’s who come in and they put in a bit of effort. It’s the same with these challenges as well, too. I love them, I think they’re absolutely fantastic because they give people the information, the education and the tools to be able to lose weight. But, if you don’t incorporate that as part of your everyday then again, very, very soon, you’re just going to revert back to the way that you were. So, it has to be something that becomes a new normal for you in terms of the way that you do things.
Matt: Yeah, that’s right.
Jeff: Anyway Matt, that’s fascinating, and we could do this a hell of a lot more, and again, we’ve probably said more than maybe we ever wanted to, but we’re coming up close to the Arnold down in Melbourne Australia where we’re launching this product. It’s going to be available from the week after that, which is around the 20th or thereabouts of March. The product is exciting, there’s a hell of a lot more to discuss about it, but I know that the research that you were doing on PPAR you specifically wanted to mention how important that was for Fat Loss and how that is one of the—I don’t want to say master components—is that fair, one of the master components?
Matt: Yeah, pretty close. It’s definitely the master sensor.
Jeff: So, if you’re combining all of these things together, manipulating the PPAR in a positive way, up-regulating the AMPK, you’ve got your Carnitine Palm…
Matt: Carnitine Palmitoyltransferase
Jeff: I’m terrible with that word.
Matt: The Carnitine Enzyme.
Jeff: Yeah, the Carnitine Enzyme. You’ve all this working, you’re reducing your Insulin, we’re laying out a pretty good strategy here for people, whether they’re at the beginning or if they’re high, high in. Like I said, the nice thing about working with the high end athletes is that they can utilise these things and tell very quickly the impact it’s going to have. So, it’s exciting.
Matt: It is.
Jeff: Matt, we’ve got some FAQs, and we got in trouble last week because we cut our FAQs really short, and Elsa is getting hammered because the FAQs are building up, so we better get into them. But, is there anything else you wanted to say on PPAR?
Matt: No, I just wanted to hear you say Adipocyte Apoptosis.
Jeff: Adipocyte Apoptosis.
Matt: Well done.
Jeff: That was pretty close.
Matt: Yeah, that’s close enough. A bit of Kiwi in there.
Matt: Bastard.
Jeff: Alright. So Matt, let’s get into some FAQs.
This one is from Marcella: “Hello, I’m very interested in your products, but I’m not sure what kind I should order. I’m trying to lose about 15 pounds in five months for my wedding. I’ve been dieting and working out, but have plateaus in my weight and have remained at a weight of 155 pounds. I am 5 foot 4 inches. Do you think it would be okay to give me any suggestions on what type of product to start out with?
Well, that’s a nice broad one that.
Matt: Yeah, it is.
Jeff: And look, how many of our listeners are in the same boat?
Matt: Yeah.
Jeff: We can get a bit technical at times, Matt. I try and dumb it down, which I think I do a pretty good job when you’re talking, but it can be a bit confusing, Matt, there’s a lot to take in.
Matt: Oh hell yeah. So, with a very general question like that I would always start with T432. There is one product within our range that generally will improve your Basal Metabolic Rate, it will work to a certain degree to create a Hormonal Profile that allows you to Burn Fat. So, it does work on Insulin, it does, to a mild degree, work on Estrogens and Androgen ratios, it’s very powerful at controlling Thyroid Hormones. So, as a general shot gun type approach to target a faster Metabolism T432 is where I’ll start. The other good thing about T432 is that you can regulate your dose by yourself, so using your Basal Body Temperature, which we can provide those charts on our webpage and everything.
Jeff: You took the words out of my mouth. I think the body temperature one is really interesting, so you can actually determine how effectively the product is working for you by taking your Metabolic Rate. If you go to our website, under the T432 I think it is, or you can search for it as well in the Search Function, type in—is it the Metabolic Chart, Matt?
Matt: I think it’s Body Temperature.
Jeff: Body Temperature Chart, and there’s a little chart there so you can actually measure your temperature. And, what should it be, Matt?
Matt: Normal is 36.8.
Jeff: So, you work to get it to that level, and I mean some people, even for short periods of time get it above that by taking a few more, not that you’d recommend that, Matt, for the long term.
Matt: Yeah, but she’s got a wedding, smash it out.
Jeff: Yeah.
Matt: So, this wedding is in five months, so the other suggestion I’d make would be the SUBCUT. So, if you combine T432 and SUBCUT you’re going to prep for your wedding, you’re going to start changing your body shape, but also, if you’ve got any little problem areas start using the SUBCUT, because it’s just going to work anyway, it’s just going to move this stuff around.
Jeff: Yeah, get out there and obviously start doing your morning Fasted Cardio which we’re a huge fan of.
Matt: Yeah, and we’ve got a product coming out soon, but yeah, you’d have time.
Jeff: Acetyl L-Carnitine as well, I’d definitely recommend. Not that we have one—actually, you know what, we should bloody well bring out a good quality one and just let people have it, Matt.
Matt: Yeah, well I’ve got some in the shed that we give to the athletes.
Jeff: In the shed? In the warehouse!
Matt: We’re in Australia.
Jeff: But yeah, I would start with that. Obviously go through and do what you hear everyone else talking about, Marcella, which is regular small meals, reduce the Sugar out of your diet, keep your water nice and high. Water is something that’s overlooked especially if you work in an office and there’s air conditioning in there, you are actually more dehydrated than what you think you are, so keep the water flowing as well, too. And, of course, avoid as many of the bad foods as you can, like the saturated sugary high fat foods, the alcohols and things like that, and that should hopefully work. But, the funny thing is, what’s been done for Fat Burning in terms of exercise and nutrition is already there, and if you look at the broad strokes, what most people are doing, that’s what I’d recommend, just to start with, some broad advice.
Okay, this one is Rebecca England: “Hi guys, you’re probably bombarded with messages daily but I’m really at my wits end so I’d love your help. So, back ground on me: Recovered Bulimic, Anorexic, a binge eater for 12 years, and yes I’ve had them all through that time. About two years ago I recovered. My Digestion is slowly getting better. I have been helped by using Psyllium Husk, Slippery Elm, Aloe, Lemon with ACV, etcetera. I have had Diarrhoea every day, never hard stools. My Digestion is still sluggish but it has improved a heap from before. Also I’ve stopped having periods for six years but after two courses on ALPHA VENUS they came back, yay. Although irregular I still have them so that’s good for me.
I eat six clean meals a day, designed by a coach, weight train and Cardio. I’m happy with where my body is going at the moment, but one thing that still seems to be a real issue is Water Retention around my hips and my stomach and the back of my Triceps, it’s so upsetting as my clothes get tight and I look doughy. I don’t know why it does this. It is not all the time but it does happen a lot and it really gets me down in the dumps, I feel heavy and gross. I take fluid away but I know I’m only treating the symptom and not the cause.
I guess my question is, do you have any suggestions of any tests that I could get done, or know what I should do? I also forgot to mention, I now take CORT RX and T432. I did listen to the podcast recently about this. I have tried natural diuretic vegetables but to no avail. I take three CORT RX three times a day, and T432 with meals. I take three of the ALPHA VENUS as well, two in the morning on an empty stomach and one with meals—one with meals three times a day, or one with meal three. “Also, I’m not sure if this is relevant but my glands under my chin and jaw are constantly swollen like giving me a double chin look, they feel like mini golf balls.
Thanks for taking the time to read my message.”
Matt, that’s from Rebecca.
Matt: Alright, cool Rebecca. For starters, before I forget, I’ll start at the back where you mentioned lumps, so I will say go to the doctor and get them checked out.
Jeff: Straight away.
Matt: Make sure they’re just glandular lumps. And, while you’re there ask them to measure for something like Epstein Bar Virus in your blood that might be an old virus loitering around that can cause those exact symptoms. So, get them to check that out and make sure it’s not anything sinister first before I go and tell you anything else.
Jeff: And, by the way, always check this information with your doctor.
Matt: Yeah, of course, it’s just a podcast.
Jeff: Of course.
Matt: So, anyway, that’s really important. But, basically, with those experiences that you’ve had with your Gut, massive changes to Calories in and out, can alter Gut Flora but especially things like Bulimia and that sort of stuff, massive changes to Gut Flora. And then, the funny thing is, we throw in things like Psyllium and Slippery Elm which are supposed to be feeding it, but if the Gut Flora is all out of whack you’re feeding the wrong Gut Flora. Things like ALPHA VENUS, the Glycosylates that are found in the Brassica that actually regulate the detoxifications of the Estrogens and that require a certain amount of Gut Flora for them to be absorbed effectively and work to their best. So, you’re probably not getting the best out of your VENUS if you don’t have your Gut Flora right, and you’re not getting the best out of your Slippery Elm and Psyllium if you don’t have your Gut Flora right. The end result is that you’re feeding the wrong Gut Flora the right foods, they love it. They cause a lot of bloating, they cause a lot of Inflammation, and that Inflammation then contributes to all the Fluid Retention, they recycle Hormones and all that sort of stuff.
Jeff: Estrogen?
Matt: Yeah. So, the place to start is, start loading up on good friendly Gut Flora, load up on things like the Inner Health and the IBS support. Try to get a variety.
Jeff: I’ve got a feeling, from the language, it might not be in Australia, Matt.
Matt: Yeah. What you’re looking for is a Lactobacillus Plantarum, that’s the most Anti-inflammatory soothing one. You’re looking for a Lactobacillus Rhamnosus which reduces the mucous and takes away the Diarrhoea, you’re looking for just a Lactobacillus Acidophilus, and a Bifidobacterium Infantis that will create the right environment feeding on the fibre to allow the other bugs to grow and thrive. So, you want to get a big broad spectrum amount of Probiotics, that will make the other products work better. Also throw in really high doses of B Vitamins, in particular you want to load up on Folate, B12, B6. Those core Cofactors help to work with the VENUS, but they all require Probiotics, they require massive colonies of organisms in your Gut to control the way these things work, and they’ve been totally screwed around with.
So, that’s where I’d basically start, with just Probiotics, start with the Gut. Stick on the VENUS, but when you fix up the Gut and you throw in the B Vitamins those symptoms that you mentioned about the Triceps and the Fluid and that, they’ll all disappear next cycle, you don’t have to worry about it, and the periods will still be irregular until we get the VENUS to work properly with its ability to detoxify the Estrogen; it’s the detoxification of the Estrogen that’s going to regulate your period and get rid of the Fluid. And, to detoxify the Estrogen you’re on the right product but you just need to add in B Vitamins and Probiotics to make it work better, just because you’ve ripped your insides apart, so we’ll just rebuild that.
Jeff: There you go Rebecca; I hope that’s helped. So, give us a hoy and let us know how you’re getting on.
Okay, Mattie, this one is from Tina: “Hi guys, I was just looking for a bit of guidance. Since coming of the pill in August my world has gone into a total spin. I lost five kilos straight up and my body has gone into meltdown. I was seeing a Naturopath to try and rebuild but he had me on so many things it just seemed to make everything worse. I ended up having issues with my Thyroid. That seemed to settle down once I stopped taking everything. The Endocrinologist said maybe I have an issue with my Adrenals. I have had blood test after blood test. My last one this week was to test my Cortisol and apparently that’s come back normal. Now, the doctor is telling me to go back on the pill and see if that helps. I’ve been to several doctors but all they want to do is put me on antidepressants straight up. I feel like I’m going mad.
I don’t feel like myself anymore, I can’t even look in the mirror. I feel like I’ve aged so much in such a short period of time, my skin is dry and scaly and my hair is falling out. I have anxiety to the point where I struggle to go to the shops. I’m usually the strong one where everything just bounces off me, now all I seem to do is cry. I used to weight train at the gym every day and now I can barely do the basics at home. When I do manage to get a couple of days at the gym I’m out for days and then any muscles I do get I soon lose.
My sleep cycle is crappy, I’m tired during the day and when it’s time for bed I sometimes struggle to go to sleep and then when I do sleep I’m usually wide awake around 3 am. Then, there are times when I have no problems going to sleep but wake up several times during the night, it’s so frustrating. And, to top it off I’m a complete scatter brain.
This is the stuff I was on: Silymarin IC , NeuroLift, Plift, Energy X, Calm-X, Hemagenics, Iron Advance, Vitamin D3 liquid, Thyroid Calm, pure encapsulation Folate 300, Methyl B12 – chewable. I had the test for the MTHFR gene—your favourite one, Matt—and came back positive but I’m not sure exactly what that means. That will be good if you can explain on that. I’m struggling with what’s happening to my body. Thank you.”
Matt, holy cow.
Matt: Oh Man.
Jeff: Do you know, one thing I’m just waiting for you to unload…
Matt: Oh, don’t say that.
Jeff: No, you know what, like [Portino]. Now, Matt, I think—yeah, anyway go for it. I’m not going to say anything.
Matt: Alright. Jeff listed off quite a few product names, and that sort of stuff. I know what’s in those formulas because I made a couple of them and I would never prescribe them for you in this.
Jeff: It’s not because they’re bad, it’s just because they’re not the right…
Matt: Not the right ones for you. I mean these are very powerful tools. You’ve got to understand that Nutraceuticals are extremely powerful. Combinations is the most important thing. You’ve got to understand the interactions and the synergies to be able to create a protocol.
Now, I didn’t do that consult, I don’t know all the details, I don’t know everything, and I only know what you read out. Okay?
Jeff: That’s true. So, we’re not attacking anyone.
Matt: So, I’m not attacking anyone, it’s just that Thyroid Calm is a product that makes your Thyroid go slower and you give it to people with Hermetically diagnosed fast Thyroid, Graves’ Disease, Hyperthyroidism, and it’s designed to slow down the Thyroid Gland to protect the heart. The problem is, if you give it to a normal person it makes your Thyroid go slow and you get diagnosed with slow Thyroid, Hashimoto’s. If you stop taking it and all of a sudden your Thyroid goes faster, it’s a massive handbrake for the Thyroid. It’s one of the slowest selling products for the whole company because its only used in very specific medically diagnosed people, and anyone that’s not in that category shouldn’t get it.
The NeuroLift, the Plift, the Energy X and the Calm-X, I mean even if you just look at the combination of an energy uplifter and a calm product stacked together, it bugs me. But, anyway, the problem is they’re all massive doses of Glutamines and Tyrosine. So, in all of those products are big doses of Glutamine, which can be converting to Glutamates aggravating anxiety and panic, and if you take too much Tyrosine and what’s going to happen, especially if you’ve got something slowing down your Thyroid, so Tyrosine potentially goes to make Thyroid Hormones, Tyrosine also makes Dopamine, Adrenaline and Noradrenaline and Phentolamine. So, if you’ve got something putting a handbrake on the Thyroid, the Tyrosine then is going to go through and make Adrenaline, which is going to fuel panic attacks and anxiety, and if you stack that with Glutamates from the excessive doses of Glutamine and you’ve got excessive nerve irritation.
Jeff: Gees.
Matt: Now, let’s go back to the start. Genetically, you have a Methylation Defect. That polymorphism in the MTHFR gene, and I didn’t even swear because this makes me cranky, this case study, so I’m not going to call it the Mother Fucker Gene, it’s the MTHFR gene. What that basically means is, Folic Acid which is found in all of those products, so Folic Acid, which is in the Hemagenics and all of those Energex, Calm-X, NeuroLift, it’s in the Folate, it’s in those sorts of things, it doesn’t bloody work. Folic Acid doesn’t work for you Tina because you’ve got an MTHFR gene polymorphism. You need to be taking 5MTHF or 510-Methylenetetrahydrofolate, that’s the activated form of Folate. That gene defect means your body cannot convert the Folic Acid in supplements or certain foods into the Methylated Folate that the body actually uses to detoxify the toxic Estrogenic Metabolite created by the pill that is still lurking in your body.
So, while you were on the pill your body was making 16-Alphahydroxyoestrone but because of the Methylation polymorphism you weren’t capable of processing the pill down the right pathway. So, the whole time you were on the pill you were making this dodgy type of Hormone that causes Anxiety, Panic Attacks, Sticky Blood, Fluid Retention, Fatigue, Clotting, it makes your brain feel weird, all that sort of stuff, it does all of those things. But, while you were on the pill it keeps it low, but when you come off the pill those levels shoot up really high. So, when you came off the pill your body was making too much [1:03:19], and all you need to do is clear that toxic metabolite away, take it away from 16=Alphahydroxyoestrone, down the pathway to make 2-Alphahydroxyoestrone, and then from 2-Alphahydroxyoestrone we’ve got to make 2-Methoxyestrone and that will protect you from most of these symptoms.
The way you do that is with Activated forms of Folic Acid. The Methyl B12 is fine because that’s an activated form of B12, but they haven’t given you an Activated form of Folate. So, what you want to do is you want to look for 5MTHF, you need at least 1000 micrograms per day, but I’d probably go 1000 micrograms twice a day, just load up. Get that Methyl B12 with it, and you need 1000 micrograms of that twice a day as well. Get an Activated B complex that contains B6; Pyridoxal 5′-Phosphate. So, you can get, for example, Thorn’s Basic B Complex, and then stack it up with some extra 5MTHF, and I’d use something like Feosol from Thorn which actually has the Activated Folate and Activated B12 in it, instead of the Hemagenics from Metagenics.
So, basically, Activated Vitamins with ALPHA VENUS, and that’s it. So, two things: you do ALPHA VENUS and you take two in the morning, two at night, and then I would take the B Vitamins. And, that’s all you need. Screwing around with Tryptophan and Tyrosine and all that brain chemistry is not going to do anything when the cause is still there. So, for measurement—if you want to measure Homocysteine levels that would be interesting to see, because that’s a marker that the body uses, it’s a good marker because it doesn’t change much, it builds up gradually over time, and the body uses Methylation to get rid of it. So, if you can’t Methylate then it builds up. But yeah, that’s basically what I’d do. It sucks, Man, I made ThryoCalm. I’m not allowed to say that. Fuck it, who cares.
Jeff: Alright, mate. Anyway, Tina, hopefully that’s helped, and again, as per usual, go and see your healthcare practitioner…
Matt: A different one.
Jeff: Find a new one.
Matt: I probably know that person. Anyway.
Jeff: I’m just going to leave that there. Tina, let us know how you get on.
Okay. This one is from Elisha: “I’ve only just started listening to your podcast as it was recommended to me by a family member because I have PCOS. It’s been great to hear you explain the condition, why things are happening and what things I need to focus on to improve and reduce my side effects in such a clear and simple way. I have started taking T432 and look forward to seeing how this will help.
My question today is around Testosterone as my partner has a condition known as Kallmann syndrome where the Pituitary Gland doesn’t produce the trigger for the body to produce Testosterone. He’s currently taking medication called Pregnyl which switches on the Gland and makes his body produce the Hormone. However, he still seems to see the effect of low Testosterone levels. Listening to the podcast you have spoken about ALPHA MARS and the positive effects it can have on increasing levels in males, and I was wondering if this product could help in this situation, and whether due to the condition it would produce the same effect?
He is currently getting blood tests completed through his doctor to determine the actual levels. I wanted him to contact you while he is in the process, so we might be able to look at a more natural way of increasing Testosterone levels rather than purely medication, if possible. Any suggestions as to whether your products might be able to assist would be great.”
Matt, what do you think? I mean if there’s a problem there, isn’t that how ALPHA MARS works, along that pathway?
Matt: Yeah, well Colman’s Syndrome is a weird one because it’s not like it’s one of those genetic problems where they’re missing glands and those sort of things, it’s as if they didn’t start puberty, or didn’t complete puberty. And, running through the same process, interacting with the Pituitary Gland to tell it to work on the Hypothalamus Pituitary Gonadal Axis can up-regulate those pathways and actually compensate for the fact that these things didn’t happen earlier.
It’s a weird one, but yeah, ALPHA MARS is really good because it does work on the Hypothalamus Pituitary Gonadal Axis. Be aware, an important note is, the HPA Axis, so the Hypothalamus Pituitary Adrenal Axis is for survival. So, it’s the trump card, it will always take priority. So, when you’re trying to work on the HPG Axis be aware that Stress, Pain, Inflammation and all that sort of stuff will drag you away from Reproductive Hormones and take you towards Survival Hormones. So, it’s important when you’re using something like ALPHA MARS just to look, and if the person’s got a lot of Stress and that sort of stuff, anything you can do to take the burden off the HPA Axis is essential or the other Axis’ aren’t allowed to work.
Jeff: So, Matt, for Elisha then—we’ll just flick her out one, we’ll send her out one. Actually, for Tina as well too, I’m just thinking. Is there anything that you recommend that we give to her?
Matt: Well, we’ve got the VENUS.
Jeff: Okay, well maybe we’ll flick out a VENUS to her as well, I feel a bit sorry for these people.
Matt: I’ve got a good staff of the Methylated Folates and stuff, but…
Jeff: Well, we’ll send out the ALPHA VENUS, and for Elisha’s partner as well too, we’ll send out the ALPHA MARS and give that a try. So, as far as medication, Matt, with the doctors with regards to…
Matt: No, it’s fine to use the Pregnyl. Pregnyl is just pregnancy Hormone, it just tricks the nuts into making something.
Jeff: Right. But, it bypasses that whole path doesn’t it?
Matt: Yeah. We want to work on the Pituitary Gland, we really want to be targeting the Pituitary Gland, and that’s why ALPHA MARS will do it, and if anything, if you’re really stressed throw in the CORT RX to take the burden off the HPA Axis and allow the HPG Axis to work.
Jeff: Alright, so I’ll do that, and I’ll tell Elsa to send out Elisha an ALPHA MARS and a CORT RX.
Matt: Yeah, sounds good.
Jeff: Alright, give them a try and see how they go. The Pregnyl obviously will work, but it just completely bypasses the Hypothalamus, doesn’t it?
Matt: Yeah.
Jeff: Alright, no worries.
Last one, Matt, this one is from Michael: “Hi gents, love the show, been listening every Friday hanging for the podcast. After 45 episodes maybe it’s time to rat Matt’s brain.”
Matt: Bullshit, we just started.
Jeff: “Gents, I’m studying at uni, do Olympic Lift 12 times per week and love it. I take the CORT RX before dinner and bed and the ALPHA PRIME before training, and the drive I get is phenomenal from the Vitex. Four days ago I managed to get between a dog fight between my American Staffy pup and another dog, and unfortunately the other dog bit straight through my fourth and fifth finger on my left hand.”
Matt: God.
Jeff: “With the bone exposed I have had surgery—Oh, I’m squirming all over the place—and on the last IV antibiotics and starting a two week course tomorrow. My question is, what can I take to help me get back to the gym faster to rebuild and help recover the cracked bone, flesh, and also to rebuild my immunity to cope with all the antibiotics once I finish them?”
Matt: Awesome.
Jeff: “Possibility to boost my immunity and fight possible lingering and nasty infections?” Thanks fellas, I just have to say the Ken Ware podcast was next level.”
I agree. We’re going back, we’re going to talk to Ken again, so we’re looking forward to some more FAQs, and I’ll give people plenty of time on that. He’s a weird guy.
Matt: That’s a good idea.
Jeff: Matt, you had a cracked bone poking through the skin?
Matt: But, I didn’t have dog juice in it. So, I’m sitting there thinking, “The infection, the Tetanus,” oh, that’s insane, I can’t believe you didn’t end up septic. But yeah, I got the fun part of the question, and this is why it’s good to be a Naturopath not a doctor, I’ve got a weak stomach for that stuff.
Jeff: Yeah, me too.
Matt: Unless it’s mine, then it’s cool. But, basically, what you want to do is you want to start the ALPHA MARS as soon as possible, four capsules a day. The Shilajit in there drives all the minerals in and makes the bones tough as nails, it really heals up things really fast, and you also want to be using the PROTOTYPE and get that all over the finger because it can heal things up extremely fast, once you’ve obviously got rid of the open wounds because it will make things bleed a little bit more.
Jeff: What about the CAPZEA, Matt?
Matt: Oh yeah, it’s alright, it’s for pain.
Jeff: It’s something for pain, but oh well, don’t worry about that, it’s the new DRAGONS BREATH coming out.
Matt: Yeah, it’s good for pain. It’s freaky too, if DRAGONS BREATH, CAPZEA it stings if it hits the wounds, it really burns and it hurts the wounds and you shouldn’t add it wounds. But, what’s freaky is, you can do it on the other hand. So, when you do get your hands on CAPZEA if you’ve got a sore right hand you can actually put it on your left hand and it still screws with the nerves and takes the edge off your pain.
Jeff: Are you for real?
Matt: Yeah, it screws around with the nerves. If you do it on exactly the same symmetrical spot on the other hand you’ll actually remove it. Next time you get an itchy spot, so if you’ve got an itchy part of your leg, scratch the exact same spot on the other leg and you’ll reduce the itchiness on that leg, because they go back to the same part of the spinal cord, so you’re just screwing with the system to say, “Yes, we’ve made change,” because all it’s asking you to do is change. Yeah, and then you’ve made change, so it goes, “Okay, I’m cool with that for now, let’s wait and see what the next signals are,” so you can screw with nerves. But yeah, ALPHA MARS and PROTOTYPE are really powerful for rebuilding and healing everything.
I had the open compound fracture in my hand and I managed to reseal the whole thing within about three weeks.
Jeff: I think it was even less than that.
Matt: Yeah, it was but that was when the X-ray was. I had an X-ray after three weeks when I insisted they take off for a fishing trip. So, yeah, that’s pretty much it, and that’s all I used, and I think the only other stuff I used was I made sure I had the actual cofactors necessary which I usually use Hydrolysed Collagens and that sort of stuff as well. I’ve got a few different ones of those, I can’t commit to any particular brand, I just keep mucking around on particular animal types of Collagen.
Jeff: Alright, well there you go, and hopefully that will help and I hope that you heal up well, Michael, and thanks for the question. In fact—what did you say, Matt? We’ll flick him out an ALPHA MARS…
Matt: ALPHA MARS and PROTOTYPE.
Jeff: PROTOTYPE, cool. Alright we’ll flick those out to Michael.
Matt: Oh, and the Immune stuff just wait until you finish the antibiotics and then load up with Probiotics.
Jeff: And, to Marcella will flick out a T432, and Rebecca, what did we recommend for Rebecca, I can’t remember?
Matt: Nothing, I think she’s too far away, we can’t help you.
Jeff: No, we said to her to go and see the doctor.
Matt: Oh, that’s right.
Jeff: Anyway…
Matt: Lucky you’re not a racehorse.
Jeff: Yeah, we’d shoot you.
Matt: Last word, Jeff? You don’t like it, do you?
Jeff: I do. You know what? Question everything.
Matt: That’s not [1:13:47], that’s stupid, I hate that.
Jeff: You know, what?
Matt: Except what we say.
Jeff: Mm. You do hate that, don’t you?
Matt: Yep.
Jeff: Well, you know what, here’s my last little word for day.
Matt: Oh, here we go, [overtalk] [1:13:59].
Jeff: I just cannot believe the amount of stupidity that’s out there on the mainstream media at the moment, and you know what? It’s like they gather these people up like a bunch of sheep with fangs to just turn on people because they don’t fit inside what they consider to be the status quo.
Matt: Or, what they’re trying to create as the status quo.
Jeff: Oh, people just seriously—and look, the funny thing is, I think that most of the people that listen to our podcasts fit outside that. And, why we haven’t gone anything near controversial because the producer of the show, which is Toni, won’t let me go anywhere near there, and it’s probably a smart move.
Matt: She’s the most controversial person I know.
Jeff: I know.
Matt: Anyway, the thing is, just keep questioning everything, and if you do it in a way that’s nice and respectful of other people’s opinions, you don’t have to be—the other thing is these keyboard warriors, they’re opinions are so strong and it’s like, “Well, you’re not going to learn anything if you’re just shouting at someone, you know.”
Jeff: They do know that it does scroll down the news feed, so by the time that it comes out that they’re wrong they don’t have to deal with it. Ohh. But anyway, it just comes down to question everything, do it in a polite way. At the end of the day, let bygones be bygones, not everybody is going to agree on everything, but the problem is that everybody’s trying to fit into the one—“You have to agree with this, and this is—ahh. I don’t know. Anyway, there you go.
Matt: There’s your last word, and I’m glad I asked.
Jeff: Yeah, well Toni will probably cut it. Anyway, thanks guys for listening, we’ll be back next week, and don’t forget we’ve got the Arnolds on in Melbourne next weekend, which is the 18th, I think, so we’re going to be down there. If you haven’t got tickets yet for the breakfast come along and see Matt and myself and the team, we’d love to have you there.
Matt: We’ve run out of tickets, they’re stuffed.
Jeff: No, I think they can still buy them.
Matt: Oh, okay.
Jeff: Yeah, we’ll be back next week.
Matt: Cool. Hooroo.
Jeff: Hooroo.

END OF TRANSCRIPT