Noway Research – Rethink Your Drink

NOWAY BODYBALANCE

BODYBALANCE® is a specific combination of bioactive dietary peptide from hydrolysed bovine collagen.

BODYBALANCE® is made using a unique process recreating a digestive process with specific acids and enzymes capable of making a specific functioning blend.

Every batch of BODYBALANCE® is tested to confirm the presence and activity of the specific peptides to ensure efficacy and consistency.

Summary of actions

  • Collagen is the most abundant protein in humans.
  • Excellent bioavailability and bio-efficacy
  • Acid: base balance – alkalizing protein NOT alkaline protein
  • Unique amino acid profile
  • muscle hypertrophy – mTOR and PAX7 activation
  • fat loss – AMP-K activation 
  • Enhanced strength and performance
  • Enhanced collagen production for more power and less pain

PROVEN through NOWAY BODYBALANCE™ science

  • Proper training can build muscle
  • Proper training with adequate macros (food, whey, vegetable protein, IIFYM) improves your results from training
  • making 15 grams of NOWAY BODYBALANCE™ part of your daily protein allocation amplifies these results significantly
  • Studies show compared to placebo…
    • 3 x more muscle growth than whey
    • 2.5 x more fat loss than whey
    • 3.75 x more power than whey

Excellent Pharmacology

You are what you eat!

Or is that you are what you absorb?

but what if it goes straight through?

You are what you eat, absorb and utilize!

Not as catchy but more accurate.

We need to cover some pharmacology theory but not get lost in the details. People can use the details to create confusion; so, let’s simplify.

Biological value is a unit of measure based on theory and assumptions = theoretical mathematical equations for absorption and amino acid profile. There is no testing of effectiveness. (“I have a good CV”)

Bioavailability is absorption and distribution. Bioavailability is a unit of measure for the ability of a product to be absorbed and delivered systemically. (“I turned up to work today”).  But again, not testing how effective the product is. Many factors will determine what dose is effective for an individual and effectiveness is not always proportional to blood levels.

Bioefficacy is actually investigating if it works. Bioefficacy is a unit of measure to show levels of effectiveness by measuring changes to anatomy and physiology. (“I actually worked today. Look! I did stuff and things!!”)

Collagen has poor biological value but NOWAY BODYBALANCE™ has excellent bioavailibity and bioefficacy

Collagen is regarded as having a low biological value compared to whey due to a unique amino acid profile with lower amounts of BCAA and lysine. However, the mixture of amino acids has been shown to be superior to whey protein in bioavailability and bioefficacy e.g. maintaining nitrogen balance and proven body composition changes in direct comparison to whey.

NOWAY BODYBALANCE ™ is made of specific functioning dietary peptides. It is not just a protein food

What makes NOWAY BODYBALANCE ™ different to other hydrolysed collagen, whey or vegetable protein supplements is that the collagen has been made by recreating a digestive process with specific acids controlling pH and enzymes to cleave amino acid chains at specific points to make a bioactive peptide.

Once it enters the gut no further digestion is needed and the full peptide is absorbed and is functional.

This allows the NOWAY BODYBALANCE ™ food to function like a powerful tool like a drug, medicine or active botanical compound in its own right before the amino acids are liberated from the peptide to be available as building blocks necessary for the required job instigated by the functional peptide.

This is the difference between supplying functional protein that forces change and supplying protein and aminos to make up your protein portion of your macros. With other proteins, the building blocks may or may not be used and they just add to the pool to be picked up and used as part of normal processes. But there is no control over where they go and what they do. It leaves too much to chance. Genetics, stress, anabolic steroids, hormonal profile, immune profile, digestion, gut health etc. can all influence how the body uses the amino acids supplied by other dietary and supplemental proteins. NOWAY BODYBALANCE ™ is different.

Bioavailability

The bioactive peptides are absorbed intact within minutes by passing across the mucosal barrier as a complete peptide that is no longer subject to enzymatic cleavage. This is rapidly followed by a high peak of systemic amino acids.

Bioefficacy

Muscle HYPERTROPHY

Nitrogen retention

Nitrogen retention is a way of measuring the availability of amino acids in your system. A marker for bioavailability and bio-efficacy. Always good to compare apples with apples so trying to show direct comparisons. Better nitrogen retention than whey. Plus, they stopped losing muscle mass and that shows efficacy. “Nitrogen excretion was higher during the whey supplement trial than during the collagen trial demonstrating the hydrolysed collagen protein maintained nitrogen balance better than whey.”

J Am Diet Assoc. 2009 Jun;109(6):1082-7. doi: 10.1016/j.jada.2009.03.003. Effects of whey and fortified collagen hydrolysate protein supplements on nitrogen balance and body composition in older women. Hays NP1, Kim H, Wells AM, Kajkenova O, Evans WJ.

mTOR pathway

The common belief is that mTOR stimulation is proportional to Leucine concentrations. However, NOWAY BODYBALANCE ™ is much lower in leucine than whey yet has been shown to be significantly more powerful than the same dosage of whey protein and leucine directly for mTOR stimulation.

In human muscle cells the RNA expression of mTOR, was statistically significantly increased in comparison with untreated control cell culture experiments (blue bars). Moreover, a statistically significantly increased mTOR level in muscle tissue after 3 months orally BCP administration suggests a positive impact of BCP for muscle formation in vivo (orange bars, mean ± SEM).

Stimulation of both mTOR production and activity shows synergy and not compensation e.g. if I blocked mTOR activity, the body may respond with increased RNA to make more and vice versa.

Improved muscle tissue synthesis via effective mTOR stimulation whey 13% and BODYBALANCE 30% more effective than placebo. BODYBALANCE IS MORE THAN TWICE AS EFFECTIVE AS WHEY FOR mTOR stimulation.

PAX7

PAX7 stimulates muscle hypertrophy via satellite cells and promotes muscle cell proliferation and muscle growth. BODYBALANCE supplementation leads to a significant increase in PAX7 compared to control.

Unique amino acid profile

High levels of bioavailable arginine

  • As the collagen peptides are absorbed intact and the amino acids are liberated in the periphery; arginine can bypass the issues with oral absorption of L-arginine from the gut and deliver it directly to the peripheral tissue.
  • Arginine induces NO vasodilation in the microvasculature of the muscle
  • Arginine aids creatine synthesis and replenishment
  • Arginine is involved in protein synthesis

High levels of Glycine

  • Works with arginine for creatine synthesis
  • Works with the hydroxyproline for connective tissue synthesis
  • Most simple amino acid building block / precursor for several pathways involved in
  • antioxidant defence systems
  • glycogen replenishment
  • neurotransmitter function

COLLAGEN IS THE MOST ABUNDANT PROTEIN IN HUMANS

Collagen is a “structure protein” and the main component of connective tissue

30% of whole body protein is collagen

10% of skeletal muscle mass is made up of collagen in the form of connective tissue.

30% of muscle power is generated by this connective tissue.

25% of the cell nuclei in muscle cells originate from connective tissue fibroblasts

Tendon: collagenous tissue that connects muscle and bone

Endomysium: collagenous tissue that wraps every single muscle fiber

Perimysium: collagenous connective tissue that bundles several muscle fibers

Epimysium: collagenous connective tissue that wraps the whole muscle

Fascia: collagenous connective tissue that covers the entire muscle, located over the layer of epimysium

Collagen for connective tissue

“This positive impact on the synthesis of collagen differentiates bioactive collagen peptides from other proteins that are normally supplemented in combination with training programs in order to increase muscle mass and strength.”

Significant increase in collagen production with BODYBALANCE compared to control

BODYBALANCE induced a 70% increase compared to placebo, while whey showed no change compared to placebo.

Pain

“The results of this study have implications for the use of collagen hydrolysate to support joint health and possibly reduce the risk of joint deterioration in a high-risk group.”

Curr Med Res Opin. 2008 May;24(5):1485-96. doi: 10.1185/030079908X291967 . Epub 2008 Apr 15. 24-Week study on the use of collagen hydrolysate as a dietary supplement in athletes with activity-related joint pain. Clark KL1, Sebastianelli W, Flechsenhar KR, Aukermann DF, Meza F, Millard RL, Deitch JR, Sherbondy PS, Albert A.

Alkalizing Protein

Don’t get caught up on whether a food is alkaline or acidic in your bowl. We need to know what it does in your body. Regulating pH of your body is multifactorial. It is not a simple matter of measuring the pH of the food you are about to eat. Amino acids and nutritional cofactors that are involved in detoxification and elimination of acidic waste, the ability of a product to prevent or create acidic metabolic waste on a cellular level via enhanced energy production or whether a product is anabolic or catabolic and to what tissue can all influence acidic burden. Just like the bioefficacy v biological value; we don’t care about your CV, let’s see how well it works in the real world.

The potential renal acid load (PRAL, mEq/d) for collagen peptides is lowest compare to e.g. whey, casein, egg white or egg yolk. Collagen is more similar to vegetables such as broccoli.

Fat loss

Amp-k and mTOR have opposing actions.

When in calorie deprivation, carbohydrate restriction, glycogen depletion or starvation; AMP-K is activated to stimulate fat burning and is catabolic in nature breaking down stored fuels to provide energy.

When in calorie surplus anabolic mTOR is activated to stimulate muscle hypertrophy.

NOWAY BODYBALANCE™ unique peptides have the ability to maximise both mTOR muscle hypertrophy and AMP-K fat burning in combination with resistance exercise. This is a fascinating aspect of this unique product.

Clinical trials have shown significant increase in fat loss with NOWAY BODYBALANCE™ in combination with resistance exercise when compared to placebo.

The exact mechanism for this observation may be multifactorial. With an increase in lean muscle mass energy expenditure and resting metabolic rate increase.

An interesting finding is that the specific bioactive collagen peptides in NOWAY BODYBALANCE™ upregulate AMP-K levels and activity.

Proving Bioefficacy

NOWAY BODYBALANCE™ has been extensively studied in humans. A summary of the most relevant trials are as follows.

In the first trial in untrained elderly NOWAY BODYBALANCE™ was shown to have significant effects in stimulating fat free muscle mass as well as strength and power compared to placebo (silicon dioxide).

The second trial on untrained middle-aged NOWAY BODYBALANCE™ was compared to whey and placebo. It was shown to have significantly better results than the same dose of whey protein isolate compared to placebo.

The third trial on young trained individuals has shown significant results in building fat free mass compared to placebo.

This combination of studies has proven bioefficacy in both trained and untrained individuals across a large range of ages in randomized double blind placebo controlled trials.

Why use 15 grams of whey? I use 30 or 40 grams!

The summary table below demonstrates that the larger doses of whey do not do anything more than the doses recommended by the makers of whey. Larger doses of whey may be marketed to be more effective but the science provided by the whey experts is different.

The scientific community has established that the optimal strategy for whey is to dose 20 grams of protein for 80 kg person is sufficient for protein synthesis. The population studied showed that 15 gram dose was appropriate based on the suggestions by the makers and scientists of whey.

Am J Clin Nutr. 2014 Jan;99(1):86-95. doi: 10.3945/ajcn.112.055517. Epub 2013 Nov 20. Myofibrillar muscle protein synthesis rates subsequent to a meal in response to increasing doses of whey protein at rest and after resistance exercise. Witard OC1, Jackman SR, Breen L, Smith K, Selby A, Tipton KD.

Front Physiol. 2015 Sep 3;6:245. doi: 10.3389/fphys.2015.00245. eCollection 2015. Nutritional interventions to augment resistance training-induced skeletal muscle hypertrophy. Morton RW1, McGlory C1, Phillips SM1.

Eur J Appl Physiol. 2014 Apr;114(4):735-42. doi: 10.1007/s00421-013-2812-7. Epub 2014 Jan 3. Whey protein intake after resistance exercise activates mTOR signaling in a dose-dependent manner in human skeletal muscle. Kakigi R1, Yoshihara T, Ozaki H, Ogura Y, Ichinoseki-Sekine N, Kobayashi H, Naito H.

* Cermak NM, Res PT, de Groot LC, Saris WH, van Loon LJ. Am J Clin Nutr. 2012 Dec;96(6):1454-64.

** Miller PE, Alexander D D, Perez V J Am Coll Nutr. 2014  33(2), 163-175.

*** Zdzieblik D, Oesser S, Baumstark MW, Gollhofer A, König D. Br J Nutr. 2015 Oct;114(8):1237-45.

*** University of Freiburg  2014 – unpublished data,

**** Unpublished data  2015 – publication in preparation

Results from the human studies

Comparison to Whey – Increase in Fat-Free Mass

 

Comparison to Whey – Decrease in Fat-Mass

 

Compared to Placebo BODYBALANCE is infinitely better than whey for waist circumference

 

 

Compared to placebo BODYBALANCE is infintely better than whey for waist circumference due to the fact that placebo outperformed whey. This is possibly due to intestinal bloating from whey in sensitive individuals that may have skewed the results.

Comparison to Whey – Increase in Muscle Power

Comparison to Whey – Body Toning Effect (Muscle Gain and Fat Loss)

 

BODYBALANCE – Superior Stimulation of mTOR

 

 

BODYBALANCE – Improved Energy Supply

 

 

Improved muscle tissue synthesis via effective AMPK stimulation

BODYBALANCE – Stimulation of Connective Tissue

 

 

Significant stimulation of muscle connective tissue – an essential requirement for muscle growth

Summary of the human studies

 

 

3 things we have learnt from these experiments

1. Proper training can build muscle in all ages

2. Proper training with adequate macros from protein (whey, vegetable protein, food, IIFYM) works and improves your results from training

3. Allocating 15 grams of your daily protein allowance to be NOWAY BODYBALANCE ™ amplifies your results