Bioavailability vs Bioefficacy

Excellent Pharmacology

You are what you eat! Or is that you are what you absorb? but what if it goes straight through?

You are what you eat, absorb and utilize!

Biological value is a unit of measure based on theory and assumptions = theoretical mathematical equations for absorption and amino acid profile. There is no testing of effectiveness. (“I have a good CV”)

Bioavailability is absorption and distribution. Bioavailability is a unit of measure for the ability of a product to be absorbed and delivered systemically. (“I turned up to work today”)

But again, not testing how effective the product is. Many factors will determine what dose is effective for an individual and effectiveness is not always proportional to blood levels.

Bioefficacy is actually investigating if it works. Bioefficacy is a unit of measure to show levels of effectiveness by measuring changes to anatomy and physiology. (“I actually worked today. Look! I did stuff and things!!”)

 

Collagen protein has poor biological value compared to Whey

Collagen is regarded as having a low biological value compared to whey due to a unique amino acid profile with lower amounts of BCAA (leucine, isoleucine and valine) and lysine.

 

NOWAY BODYBALANCE ™ has excellent bioavailibity and bioefficacy

However, the mixture of bioactive peptides and amino acids in NOWAY BODYBALANCE has been demonstrated in studies to be superior to whey protein in bioavailability and bioefficacy.

This is the difference between supplying functional protein that forces change and supplying protein and aminos to make up your protein portion of your macros. With other proteins, the building blocks may or may not be used and they just add to the pool to be picked up and used as part of normal processes. But there is no control over where they go and what they do. It leaves too much to chance. Genetics, stress, anabolic steroids, hormonal profile, immune profile, digestion, gut health etc. can all influence how the body uses the amino acids supplied by other dietary and supplemental proteins. NOWAY BODYBALANCE ™ is different.

 

Bioavailability

The bioactive peptides are absorbed intact within minutes by passing across the mucosal barrier as a complete peptide that is no longer subject to enzymatic cleavage. This is rapidly followed by a high peak of systemic amino acids.

Bioefficacy compared to whey

mTOR pathway

The common belief is that mTOR stimulation is proportional to Leucine concentrations. However, NOWAY BODYBALANCE ™ is much lower in leucine than whey yet has been shown to be significantly more powerful than the same dosage of whey protein and leucine directly for mTOR stimulation.

Figure 1 In human muscle cells the RNA expression of mTOR, was statistically significantly increased in comparison with untreated control cell culture experiments (blue bars).

Figure 2 direct comparison of BODYBALANCE v. leucine for mTOR synthesis

Figure 3 Improved muscle tissue synthesis via effective mTOR stimulation –  Whey 13% and BODYBALANCE 30% more effective than placebo. BODYBALANCE IS MORE THAN TWICE AS EFFECTIVE AS WHEY FOR mTOR stimulation. BODYBALANCE ™ is much lower in leucine than whey yet has been shown to be significantly more powerful than the same dosage of whey protein and leucine directly for mTOR stimulation.